The value of neurohumoral regulation in the outcome of multiple organ failure syndrome in sepsis

The objective: to present information about potential mechanisms of development of sepsis-associated encephalopathy, and its potential role in sepsis outcome.Neurohumoral regulation is the most important system that integrates many functions of variable values to achieve the final result that is beneficial for the host. The central nervous system (CNS) is the switch and control mechanism responsible for the functioning of this system. The increasing number of studies indicating the relationship between the development of sepsis and occurrence of qualitative and quantitative changes in the central nervous system suggests that it is the degree of damage to neurohumoral regulation mechanisms at the very beginning of the disease can significantly determine the severity of the course and prognosis of the outcome of multiple organ failure syndrome in sepsis.