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Evaluating quality of life and pulmonary function of long-term survivors of non-small cell lung cancer treated with radical or postoperative radiotherapy
- Publication Year :
- 2009
- Publisher :
- Lippincott Williams & Wilkins, 2009.
-
Abstract
- Background: Our aim in the present study was to describe the quality of life (QOL), evaluate pulmonary function, and compare demographic and clinical characteristics with QOL in long-term survivors of non-small cell lung cancer treated with radical or postoperative radiotherapy. Methods: Twenty-eight patients were recruited in the study. QOL was evaluated using The European Organization for Research and Treatment of Cancer, Quality of Life Core Questionnaire (EORTC QLQ-C30, v.3). Statistical analysis was performed by SPSS 14. Results: Patients' files were reviewed in October 2006. Median duration of follow-up was 46 months (range: 25-125 months). Seven of 9 scales were found to meet the minimal reliability limit (Cronbach's alpha >0.70). The lowest and highest reliability coefficients were 0.56 and 0.93 for social and role functioning, respectively. All interscale correlations were statistically significant (P < 0.01). The strongest positive correlation was found between physical functioning and, role and cognitive functioning (r = 0.59, r = 0.37 or P = 0.01, P = 0.05, respectively). The highest correlation of EORTC QLQ-C30 and the Katnofsky performance scale (KPS) during the questionnaire was found to be with physical functioning and constipation (r = 0.41. r = 0.44 or P = 0.02, P = 0.01, respectively). When the effect of various demographic and clinical parameters on QOL was evaluated; initial KPS, age, educational level, health insurance status, stage, chemotherapy, comorbid disease, and passive smoking were determined as significant factors influencing QOL. Physical, role, cognitive, and emotional functions were found to be significantly lower in the presence of dyspnea (r = 0.42, r = 0.58, r = 0.50, r = 0.63 or P = 0.02, P < 0.01, P < 0.01, P < 0.05, respectively). Regarding the symptom scales, dyspnea was found to be correlated with increasing of fatigue, pain, insomnia, and appetite loss (r = 0.52, r = 0.40, r = 0.64, r = 0.38 or P < 0.01, P = 0.03, P < 0.05, P = 0.04, respectively). The parameters of pulmonary function tests (FEV1, FVC, and FEV1/FVC) did not show any significant relation with any scale of QOL. Conclusion: Overall, we found that QOL of our patients who survived at least 2 years after radiotherapy, was good. The Turkish version of the EORTC QLQ-C30, v.3 is a valid and reliable instrument for Turkish lung cancer patients and can be used in clinical studies. We believe further studies are needed to have a better understanding of patients' pretreatment and posttreatment .
- Subjects :
- Oncology
Male
Questionnaires
Survival rate
medicine.medical_treatment
Comorbidity
Medical record review
Carboplatin
Cognition
Health insurance
Surveys and Questionnaires
Lung
Etoposide
Survival time
Long Term Survivor
Correlation analysis
Respiratory function tests
Reliability
Prognosis
Statistical analysis
Cancer chemotherapy
Functional assessment
Survivor
Neoplasm recurrence, local
Forced expiratory volume
Human
medicine.medical_specialty
Tumor recurrence
Insomnia
Paclitaxel
Clinical article
Article
Validity
Education
Postoperative care
Age
Ex-smokers
Humans
Lung small cell cancer
Lung tumor
Aged
Questionnaire
Research Management
Quality of Life
Patient-Reported Outcome
Follow up
medicine.disease
Social status
Radiation therapy
Dyspnea
Comparative study
Cisplatin
Cancer Research
Cancer staging
Pulmonary function testing
Quality of life
Non-small cell lung cancer
Lung neoplasms
Long-term survivor
Respiratory symptoms
Survivors
Prospective cohort study
Middle aged
Evaluation
Breast-cancer
Fatigue
Follow-up
Statistical significance
humanities
Anorexia
Lung non small cell cancer
Cancer radiotherapy
Female
Adult
Pulmonary function
Pain
Karnofsky performance status
Emotionality
Pathophysiology
Cronbach alpha coefficient
Internal medicine
Passive smoking
Carcinoma
medicine
Postoperative period
Mortality
Prospective study
Lung cancer
Radiotherapy
business.industry
Carcinoma, non-small-cell lung
Gemcitabine
Cancer survival
Lung function
Lung function test
Surgery
European-organization
business
Eortc qlq-c30
Prospective studies
Constipation
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....e7ba28da8e62ef7865f79b72fe6d09cb