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ADAMTS13 activity as a novel risk factor for incident type 2 diabetes mellitus: a population-based cohort study
- Source :
- Diabetologia, 60(2), 280-286. Springer-Verlag, Diabetologia
- Publication Year :
- 2017
-
Abstract
- Aims/hypothesis ADAMTS13 is a protease that breaks down von Willebrand factor (VWF) multimers into smaller, less active particles. VWF has been associated with an increased risk of incident type 2 diabetes mellitus. Here, we determine whether ADAMTS13 activity and VWF antigen are associated with incident diabetes. Methods This study included 5176 participants from the Rotterdam Study, a prospective population-based cohort study. Participants were free of diabetes at baseline and followed up for more than 20 years. Cox proportional hazards models were used to examine the association of ADAMTS13 activity and VWF antigen with incident diabetes. Results ADAMTS13 activity was associated with an increased risk of incident diabetes (HR 1.17 [95% CI 1.08, 1.27]) after adjustment for known risk factors and VWF antigen levels. Although ADAMTS13 activity was positively associated with fasting glucose and insulin, the association with incident diabetes did not change when we adjusted for these covariates. ADAMTS13 activity was also associated with incident prediabetes (defined on the basis of both fasting and non-fasting blood glucose) after adjustment for known risk factors (HR 1.11 [95% CI 1.03, 1.19]), while the VWF antigen level was not. VWF antigen was associated with incident diabetes, but this association was attenuated after adjustment for known risk factors. Conclusions/interpretation ADAMTS13 activity appears to be an independent risk factor for incident prediabetes and type 2 diabetes. As the association between ADAMTS13 and diabetes did not appear to be explained by its cleavage of VWF, ADAMTS13 may have an independent role in the development of diabetes. Electronic supplementary material The online version of this article (doi:10.1007/s00125-016-4139-5) contains peer-reviewed but unedited supplementary material, which is available to authorised users.
- Subjects :
- 0301 basic medicine
Blood Glucose
Male
Epidemiology
Endocrinology, Diabetes and Metabolism
Type 2 diabetes
MICROVASCULAR DYSFUNCTION
Von Willebrand factor
030204 cardiovascular system & hematology
INCREASE
0302 clinical medicine
Risk Factors
hemic and lymphatic diseases
1114 Paediatrics And Reproductive Medicine
Medicine
Insulin
Prediabetes
Prospective Studies
INSULIN-RESISTANCE
biology
FACTOR-CLEAVING PROTEASE
Incidence
Diabetes
MEN
Fasting
Middle Aged
ADAMTS13
3. Good health
ISCHEMIC-STROKE
1117 Public Health And Health Services
cardiovascular system
Female
Life Sciences & Biomedicine
Cohort study
circulatory and respiratory physiology
VonWillebrand factor
congenital, hereditary, and neonatal diseases and abnormalities
medicine.medical_specialty
VON-WILLEBRAND-FACTOR
ADAMTS13 Protein
Article
03 medical and health sciences
Endocrinology & Metabolism
SDG 3 - Good Health and Well-being
Internal medicine
Diabetes mellitus
Internal Medicine
Humans
Risk factor
Aged
Proportional Hazards Models
Science & Technology
business.industry
Type 2 Diabetes Mellitus
1103 Clinical Sciences
medicine.disease
ROTTERDAM
030104 developmental biology
Endocrinology
MYOCARDIAL-INFARCTION
Diabetes Mellitus, Type 2
Immunology
ENDOTHELIAL DYSFUNCTION
biology.protein
business
Subjects
Details
- ISSN :
- 0012186X
- Database :
- OpenAIRE
- Journal :
- Diabetologia, 60(2), 280-286. Springer-Verlag, Diabetologia
- Accession number :
- edsair.doi.dedup.....e80b3d8b537ef6b0ed0771ace4541e21