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Area under the curve calculations as a tool to compare the efficacy of equine influenza vaccines—a retrospective analysis of three independent field trials
- Source :
- Journal of Immunological Methods. 264:11-17
- Publication Year :
- 2002
- Publisher :
- Elsevier BV, 2002.
-
Abstract
- Using the area under the curve (AUC) concept as is commonly used in pharmaceutical bioequivalence studies, the bioequivalence of three equine influenza vaccines was demonstrated. A retrospective analysis was performed using this technique on data generated in three trials in which each of the three vaccines had been used. In total, data from 63 pony and horse foals were used. The AUC of the single radial hemolysis (SRH) titres against Influenza A/equi-1/Prague/56 (Pr/56), A/equi-2/Newmarket-1/93, and A/equi-2/Suffolk/89 (Suf/89) were calculated for each horse. It was concluded that calculation of the AUC from four time-points permitted a suitable estimate for vaccine potency. Using pooled data, it appeared that the AUC permitted better evaluation of vaccine potency than simply considering the highest post vaccinal titre (Titremax). In two studies, a minimal value for the AUC was associated with protection against Influenza (H3N8) challenge 50-153 days later.
- Subjects :
- Immunodiffusion
Veterinary medicine
Immunology
Orthomyxoviridae
Immunization, Secondary
Equine influenza
Bioequivalence
Antibodies, Viral
Injections, Intramuscular
Orthomyxoviridae Infections
biology.animal
Animals
Immunology and Allergy
Medicine
Horses
Retrospective Studies
Blood Specimen Collection
biology
Pony
business.industry
Vaccination
Area under the curve
Horse
biology.organism_classification
Clinical trial
Vaccine Potency
Therapeutic Equivalency
Influenza A virus
Influenza Vaccines
Area Under Curve
Horse Diseases
business
Subjects
Details
- ISSN :
- 00221759
- Volume :
- 264
- Database :
- OpenAIRE
- Journal :
- Journal of Immunological Methods
- Accession number :
- edsair.doi.dedup.....e818d2824e011329bd5a84853bace38d