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Association of circulating Vitamin D with colorectal cancer depends on Vitamin D-binding protein isoforms: A pooled, nested, case-control study
- Source :
- JNCI Cancer Spectrum, JNCI Cancer Spectrum, 2020, 4 (1), ⟨10.1093/jncics/pkz083⟩, Gibbs, D C, Song, M, McCullough, M L, Um, C Y, Bostick, R M, Wu, K, Flanders, W D, Giovannucci, E, Jenab, M, Brustad, M, Tjonneland, A, Perez-Cornago, A, Trichopoulou, A, Tsilidis, K K, Hultdin, J, Gurrea, A B, Bueno-de-Mesquita, B, Mahamat-Saleh, Y, Kuehn, T, Gunter, M J, Weiderpass, E & Fedirko, V 2020, ' Association of Circulating Vitamin D With Colorectal Cancer Depends on Vitamin D-Binding Protein Isoforms : A Pooled, Nested, Case-Control Study ', JNCI Cancer Spectrum, vol. 4, no. 1 . https://doi.org/10.1093/jncics/pkz083
- Publication Year :
- 2019
- Publisher :
- Oxford University Press, 2019.
-
Abstract
- Background Higher circulating 25-hydroxyvitamin-D [25(OH)D] concentrations are consistently inversely associated with colorectal cancer (CRC) risk in observational studies. However, it is unknown whether this association depends on the functional GC-rs4588*A (Thr436Lys) variant encoding the vitamin D–binding protein-2 (DBP2) isoform, which may affect vitamin D status and bioavailability. Methods We analyzed data from 1710 incident CRC cases and 1649 incidence-density–matched controls nested within three prospective cohorts of mostly Caucasians. Study-specific incidence rate ratios (RRs) for associations of prediagnostic, season-standardized 25(OH)D concentrations according to DBP2 isoform with CRC were estimated using multivariable unconditional logistic regression and were pooled using fixed-effects models. All statistical significance tests were two-sided. Results The odds of having 25(OH)D concentrations less than 50 nmol/L (considered insufficient by the Institute of Medicine) were 43% higher for each DBP2-encoding variant (rs4588*A) inherited (per DBP2 odds ratio [OR] = 1.43, 95% confidence interval [CI] = 1.27 to 1.62, Ptrend = 1.2 × 10−8). The association of 25(OH)D concentrations with CRC risk differed by DBP2: 25(OH)D concentrations considered sufficient (≥ 50 nmol/L), relative to deficient ( Conclusions Our results suggest that the 25(OH)D-CRC association may differ by DBP isoform, and those with a DBP2-encoding genotype linked to vitamin D insufficiency may particularly benefit from adequate 25(OH)D for CRC prevention.
- Subjects :
- Vitamin
25-HYDROXYVITAMIN D
D SUPPLEMENTATION
Cancer Research
medicine.medical_specialty
Vitamin D-binding protein
[SDV]Life Sciences [q-bio]
Lower risk
Gastroenterology
CALCIUM
Article
vitamin D deficiency
SERUM
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
D-RECEPTOR
GENETIC-VARIANTS
GC-GLOBULIN
Internal medicine
Vitamin D and neurology
Medicine
GENOME-WIDE ASSOCIATION
030304 developmental biology
RISK
0303 health sciences
Cancer och onkologi
Science & Technology
VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801
business.industry
Odds ratio
medicine.disease
PREVENTION
Confidence interval
3. Good health
Oncology
chemistry
030220 oncology & carcinogenesis
Cancer and Oncology
Nested case-control study
VDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801
business
Life Sciences & Biomedicine
Subjects
Details
- Language :
- English
- ISSN :
- 25155091
- Database :
- OpenAIRE
- Journal :
- JNCI Cancer Spectrum, JNCI Cancer Spectrum, 2020, 4 (1), ⟨10.1093/jncics/pkz083⟩, Gibbs, D C, Song, M, McCullough, M L, Um, C Y, Bostick, R M, Wu, K, Flanders, W D, Giovannucci, E, Jenab, M, Brustad, M, Tjonneland, A, Perez-Cornago, A, Trichopoulou, A, Tsilidis, K K, Hultdin, J, Gurrea, A B, Bueno-de-Mesquita, B, Mahamat-Saleh, Y, Kuehn, T, Gunter, M J, Weiderpass, E & Fedirko, V 2020, ' Association of Circulating Vitamin D With Colorectal Cancer Depends on Vitamin D-Binding Protein Isoforms : A Pooled, Nested, Case-Control Study ', JNCI Cancer Spectrum, vol. 4, no. 1 . https://doi.org/10.1093/jncics/pkz083
- Accession number :
- edsair.doi.dedup.....e8277737d0035994bf3d9cba7121e4da