Evaluation of CorvisST biomechanical parameters and anterior segment optical coherence tomography for diagnosing forme fruste keratoconus

Purpose To investigate the utility of biomechanical property measurements using a Scheimpflug-based tonometer (SBT) and/or anterior segment optical coherence tomography (AS-OCT) for diagnosing forme fruste keratoconus (FFK). Methods In this retrospective interventional case series, 23 eyes with FFK of 23 consecutive patients and 52 eyes of 52 healthy volunteers who visited our keratoconus outpatient clinic were enrolled. Logistic regression analysis was conducted to determine the causal relationship between FFK diagnosis and each parameter. Results When only SBT was used, the corneal stiffness parameter, stiffness parameter A1 (SP-A1) and the corneal velocity at first applanation were selected as explanatory variables, and sensitivity, specificity and area under the receiver operating characteristic curve (AUROC) were 82.9%, 86.9% and 0.938, respectively. When only AS-OCT parameters were used, the posterior corneal asymmetric component and central corneal thickness were selected, and the sensitivity, specificity and AUROC were 82.6%, 94.2% and 0.893, respectively. When parameters from both methods were used, SP-A1 and the posterior corneal asymmetry component derived from Fourier analysis were selected as explanatory variables, and sensitivity, specificity and AUROC were 91.30%, 90.38% and 0.947, respectively. No significant differences in AUROC were observed between diagnoses using each device and the combination of both devices (AS-OCT versus SBT, p = 0.314; integrated parameters versus AS-OCT, p = 0.081; integrated parameters versus SBT, p = 0.234). Conclusion Optimization of SBT and AS-OCT parameters allowed for the diagnosis of FFK at a clinically usable level. Forme fruste keratoconus (FFK) diagnosis integrating biomechanical properties with AS-OCT showed no superiority compared to diagnosis based on a single device.