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Depletion of WNT10A Prevents Tumor Growth by Suppressing Microvessels and Collagen Expression
- Source :
- International Journal of Medical Sciences
- Publication Year :
- 2019
- Publisher :
- Ivyspring International Publisher, 2019.
-
Abstract
- Background: We recently reported that WNT10A plays a pivotal role in wound healing by regulating collagen expression/synthesis, as the depletion of WNT10A dramatically delays skin ulcer formation. WNT signaling also has a close correlation with the cancer microenvironment and proliferation, since tumors are actually considered to be 'unhealing' or 'overhealing' wounds. To ascertain the in vivo regulatory functions of WNT10A in tumor growth, we examined the net effects of WNT10A depletion using Wnt10a-deficient mice (Wnt10a -/-). Methods and Results: We subjected C57BL/6J wild-type (WT) or Wnt10a -/- mice to murine melanoma B16-F10 cell transplantation. Wnt10a -/- mice showed a significantly smaller volume of transplanted melanoma as well as fewer microvessels and less collagen expression and more necrosis than WT mice. Conclusions: Taken together, our observations suggest that critical in vivo roles of Wnt10a-depleted anti-stromagenesis prevent tumor growth, in contrast with true wound healing/scarring.
- Subjects :
- Male
Skin Neoplasms
Necrosis
Melanoma, Experimental
Nerve Tissue Proteins
03 medical and health sciences
0302 clinical medicine
In vivo
Cell Line, Tumor
medicine
Animals
Wnt10a-deficient mice (Wnt10a-/-)
Tumor growth
collagen expression
Microvessel
Mice, Knockout
Chemistry
Melanoma
Wnt signaling pathway
General Medicine
Skin ulcer
medicine.disease
WNT10A
Mice, Inbred C57BL
Wnt Proteins
tumor growth
microvessel
Microvessels
Cancer research
Female
030211 gastroenterology & hepatology
Collagen
Stromal Cells
medicine.symptom
Wound healing
Gene Deletion
Research Paper
Subjects
Details
- ISSN :
- 14491907
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- International Journal of Medical Sciences
- Accession number :
- edsair.doi.dedup.....e870c4922fccb536ed4e4b0183dcda4f