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Extracellular vesicles derived from mesenchymal cells: Perspective treatment for cutaneous wound healing in pediatrics
- Publication Year :
- 2018
-
Abstract
- Aim: We evaluated the effects of the intradermal injection of extracellular vesicles (EVs) derived from adipose stem cells (ASC-EVs) and bone marrow cells (BM-EVs) in an experimental cutaneous wound repair model. Methods: Mesenchymal stem cells (MSCs) were in vitro expanded from adipose (ASC) or BM tissues (BM-MSC) of rabbits. EVs were separated from the supernatants of confluent ASC and BM-MSCs. Two skin wounds were induced in each animal and treated with MSC or EV injections. Histological examination was performed postinoculation. Results: EV-treated wounds exhibited a better restoration compared with the counterpart MSC treatment. ASC-EV-treated wounds were significantly better than BM-EVs (p = 0.036). Conclusion: EV topical inoculation provides restored architecture during cutaneous wound healing and represents a promising solution for regenerative medicine in children.
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
Embryology
Biomedical Engineering
Adipose tissue
Bone Marrow Cells
Regenerative medicine
03 medical and health sciences
children
Cell-Derived Microparticles
medicine
Animals
Humans
cutaneous wound repair
Intradermal injection
mesenchymal stem cells
Wound Healing
animal model
extracellular vesicles
Adipose Tissue
Female
Mesenchymal Stem Cells
Rabbits
Wounds and Injuries
business.industry
Mesenchymal stem cell
In vitro
030104 developmental biology
medicine.anatomical_structure
Bone marrow
Stem cell
Wound healing
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....e886f8ddf9db7e709a9ecdbe7826eaa8