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Long-term treatment by ACE inhibitors and angiotensin receptor blockers in children with Alport syndrome
- Source :
- Pediatric Nephrology. 31:67-72
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- The aim of this study was to analyze the long-term efficacy and safety of angiotensin-converting enzyme inhibitor (ACEi) and ACEi + angiotensin receptor blocker (ARB) treatments in a cohort of children with Alport syndrome (AS). This was a respective review of 79 Chinese children with AS who received ACEi alone or combined ACEi + ARB therapy. The mean age of the pediatric patients with AS at onset of treatment was 8.6 ± 4.1 (range 1.5–16.3) years. The mean duration of follow-up was 2.5 ± 1.8 (range 0.5–7.8) years. For analysis, we separated the children into three groups according to proteinuria level before treatment, namely
- Subjects :
- Male
Nephrology
Angiotensin receptor
Time Factors
030232 urology & nephrology
Angiotensin-Converting Enzyme Inhibitors
Nephritis, Hereditary
030204 cardiovascular system & hematology
Kidney
urologic and male genital diseases
Severity of Illness Index
chemistry.chemical_compound
0302 clinical medicine
Child
Proteinuria
Age Factors
Phenotype
Treatment Outcome
Child, Preschool
Creatinine
Disease Progression
Drug Therapy, Combination
Female
medicine.symptom
medicine.drug
Collagen Type IV
China
Heterozygote
medicine.medical_specialty
Adolescent
Urology
Renal function
03 medical and health sciences
Internal medicine
Severity of illness
medicine
Humans
Genetic Predisposition to Disease
cardiovascular diseases
Alport syndrome
Retrospective Studies
business.industry
Infant
medicine.disease
Endocrinology
chemistry
Mutation
Pediatrics, Perinatology and Child Health
ACE inhibitor
Kidney Failure, Chronic
business
Angiotensin II Type 1 Receptor Blockers
Biomarkers
Subjects
Details
- ISSN :
- 1432198X and 0931041X
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Pediatric Nephrology
- Accession number :
- edsair.doi.dedup.....e890d744d379d5746eb0977c1f20ff47