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Role of 5-Hydroxytryptamine2C Receptors in Marble-Burying Behavior in Mice
- Source :
- Biological and Pharmaceutical Bulletin. 35:376-379
- Publication Year :
- 2012
- Publisher :
- Pharmaceutical Society of Japan, 2012.
-
Abstract
- We examined the role of 5-hydroxytryptamine(2C) (5-HT(2C)) receptors in marble-burying behavior in mice. When administered alone, the selective 5-HT(2C) agonist WAY161503 (3 mg/kg) inhibited marble-burying behavior. Moreover, the selective 5-HT(2C) antagonist SB242084 (3 mg/kg) reversed the inhibition of marble-burying behavior by 2,5-dimethoxy-4-iodoamphetamine (DOI) (1 mg/kg) or WAY161503 (3 mg/kg). Similarly, SB242084 (1 mg/kg) reversed the inhibition of marble-burying behavior by fluvoxamine (30 mg/kg) or paroxetine (3 mg/kg). These results suggest that 5-HT(2C) receptors play a role in marble-burying behavior in mice.
- Subjects :
- Male
Agonist
Obsessive-Compulsive Disorder
Indoles
medicine.drug_class
Aminopyridines
Pharmaceutical Science
Fluvoxamine
Motor Activity
Pharmacology
Marble burying
Mice
Fluoxetine
Receptor, Serotonin, 5-HT2C
medicine
Animals
Receptor
Mice, Inbred ICR
Behavior, Animal
Chemistry
Amphetamines
Antagonist
General Medicine
Paroxetine
Anesthesia
Serotonin 5-HT2 Receptor Antagonists
Serotonin 5-HT2 Receptor Agonists
Selective Serotonin Reuptake Inhibitors
medicine.drug
Subjects
Details
- ISSN :
- 13475215 and 09186158
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Biological and Pharmaceutical Bulletin
- Accession number :
- edsair.doi.dedup.....e8a6f569552379af58d66e2956307237