Back to Search
Start Over
Intron 2 (T/C) CYP46 Polymorphism Is Associated with Alzheimer’s Disease in Chinese Patients
- Source :
- Dementia and Geriatric Cognitive Disorders. 22:399-404
- Publication Year :
- 2006
- Publisher :
- S. Karger AG, 2006.
-
Abstract
- Background: Cholesterol metabolism has been implicated in the pathophysiology of Alzheimer’s disease (AD), and cholesterol-related genes are plausible candidate genes for AD. Genetic association of CYP46A1 polymorphisms with AD had been under extensive investigations; however, observations on intron 2 T→C (rs754203) generated inconclusive results. Objective: To analyse an independent data set in a Chinese population to see whether the polymorphic site rs754203 of the CYP46A1 gene is associated with AD. Methods: We analysed 130 sporadic AD patients and 110 healthy controls of the Southern Chinese origin. Results: An association between the genotype frequency and AD was suggested in the general population (p = 0.047, odds ratio, OR = 1. 61, 95% confidence interval, CI = 0.96–2.70), while the association was most significant in the apolipoprotein E (ApoE) Ε4-negative group (p = 0.004, OR = 2.54, 95% CI =1.31–4.95). Linkage disequilibrium block prediction results also favoured this association. Consistent with previous reports, intron 3 C→T (rs4900442) polymorphism did not show any evidence of association; in our data set ApoEΕ4 was confirmed to be a genetic risk factor for AD (p = 0.0016, OR = 2.76, 95% CI = 1.50–5.11).
- Subjects :
- Male
Candidate gene
medicine.medical_specialty
Genotype
Cognitive Neuroscience
Apolipoprotein E4
Disease
Polymerase Chain Reaction
Degenerative disease
Asian People
Alzheimer Disease
Internal medicine
Cholesterol 24-Hydroxylase
medicine
Humans
Dementia
Gene
Alleles
Aged
Aged, 80 and over
Genetics
Polymorphism, Genetic
Intron
medicine.disease
Introns
Pathophysiology
Psychiatry and Mental health
Endocrinology
Steroid Hydroxylases
Female
lipids (amino acids, peptides, and proteins)
Geriatrics and Gerontology
Alzheimer's disease
Psychology
Subjects
Details
- ISSN :
- 14219824 and 14208008
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Dementia and Geriatric Cognitive Disorders
- Accession number :
- edsair.doi.dedup.....e8b6bd589e8f8e385e56f9dad7cd6b88