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Synthesis and insecticidal activity of novel 1,2,4-triazole derivatives containing trifluoroacetyl moieties
- Source :
- Molecular Diversity. 26:2149-2158
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- A series of compounds containing trifluoroacetyl groups were synthesized, and their insecticidal activity against Nilaparvata lugens and Aphis craccivora was evaluated. The compound structure was identified by NMR, HRMS, and single-crystal diffraction. The bioassay results indicated that compound 4-1 (R1 is chloropyridine, R2 is H), 4-2 (R1 is chlorothiazole, R2 is H) and 4-19 (R1 is benzyl, R2 is isopropyl) had the best activity against Nilaparvata lugens (93.5%, 94.1% and 95.5%) at 100 mg/L concentration. The effect of different substituents of R1 or R2 on the activity was studied through the structure–activity relationship. Molecular docking of compounds 4-1 and 4-2 was discussed.
- Subjects :
- Insecticides
Molecular Structure
Chemistry
Organic Chemistry
1,2,4-Triazole
General Medicine
Triazoles
Medicinal chemistry
Catalysis
Molecular Docking Simulation
Inorganic Chemistry
Structure-Activity Relationship
chemistry.chemical_compound
Aphids
Drug Discovery
Animals
Bioassay
Physical and Theoretical Chemistry
Aphis craccivora
Molecular Biology
Compound structure
Isopropyl
Information Systems
Subjects
Details
- ISSN :
- 1573501X and 13811991
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Molecular Diversity
- Accession number :
- edsair.doi.dedup.....e8c4152aaff29aa779624cd85210dfbd