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The Kollias legacy: Skin autofluorescence and beyond
- Source :
- Experimental Dermatology. 26:858-860
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- In a paper published at the J Invest Dermatol in 1998 Nik Kollias and coworkers described distinct changes in skin native fluorescence associated with skin aging and photoaging, using in vivo fluorescence excitation spectroscopy. The assignment of the 295 nm band to tryptophan fluorescence had a profound significance influencing many later studies from multiple groups. The reproducible changes in skin native fluorescence suggested that aging causes predictable alterations in both the epidermis and the dermis, whereas chronic UV exposure induces the appearance of new fluorophores. This seminal, but insufficiently widely appreciated work deserves re-examination as it points to important horizons in future experimental dermatology, such as cancer diagnostics, diabetes, wound healing, and understanding skin aging and photoaging mechanisms.
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
Photoaging
Dermatology
History, 21st Century
Biochemistry
Fluorescence
Skin Aging
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Dermis
Tryptophan fluorescence
In vivo fluorescence
medicine
Humans
Molecular Biology
integumentary system
business.industry
Tryptophan
Skin autofluorescence
History, 20th Century
medicine.disease
United States
Spectrometry, Fluorescence
030104 developmental biology
medicine.anatomical_structure
Epidermis
business
Wound healing
Subjects
Details
- ISSN :
- 09066705
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Experimental Dermatology
- Accession number :
- edsair.doi.dedup.....e8cdf7899a9ed735a5659163994da9e1