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Low Alcohol and Cigarette Use Is Associated to the Risk of Developing Chronic Pancreatitis
- Source :
- Pancreas. 46(2)
- Publication Year :
- 2016
-
Abstract
- Objectives The aim of this study was to investigate the contribution of smoking and alcohol intake and pancreas divisum on the risk of developing chronic pancreatitis (CP). Methods Consecutive patients with CP who underwent secretin-enhanced magnetic resonance cholangiopancreatography were compared with consecutive patients without pancreatic disease who underwent secretin-enhanced magnetic resonance cholangiopancreatography for irritable bowel syndrome. Results We enrolled 145 consecutive CP patients and 103 irritable bowel syndrome patients from 2010 to 2014. In a univariate analysis, statistically significant differences in sex, mean age, and the duration and amount of cigarette and alcohol use were found. Per a receiver operating characteristic curve analysis, thresholds for cigarette and alcohol consumption were, respectively, 5.5 cigarettes and 13.5 g daily. In a multivariate analysis, independent risk factors for CP were male sex (odds ratio [OR], 2.05), smoking more than 5.5 cigarettes per day (OR, 2.72), and drinking more than 13.5 g/d (OR, 6.35). Conclusions In an Italian population, we confirmed smoking and alcohol as cofactors in the development of CP. This study shows that alcohol intake and smoking habits are 2 of the most important risk factors for the development of CP.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Pancreatic disease
Alcohol Drinking
Cholangiopancreatography, Magnetic Resonance
Endocrinology, Diabetes and Metabolism
Drinking
Pancreas divisum
Cystic Fibrosis Transmembrane Conductance Regulator
Gastroenterology
03 medical and health sciences
CFTR gene
0302 clinical medicine
Endocrinology
Risk Factors
Internal medicine
Pancreatitis, Chronic
medicine
Internal Medicine
Humans
Pancreatitis, chronic
Pancreas
Irritable bowel syndrome
Univariate analysis
Magnetic resonance cholangiopancreatography
medicine.diagnostic_test
Hepatology
business.industry
Smoking
Pancreatic Diseases
Odds ratio
Middle Aged
medicine.disease
Male sex
Logistic Models
Smoking threshold
030220 oncology & carcinogenesis
Multivariate Analysis
Mutation
Pancreatitis
030211 gastroenterology & hepatology
Female
business
Alcohol and tobacco
Subjects
Details
- ISSN :
- 15364828
- Volume :
- 46
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Pancreas
- Accession number :
- edsair.doi.dedup.....e8d428a83cc6c6358242708f63f7ae01