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Low-Intensity Ultrasound Causes Direct Excitation of Auditory Cortical Neurons
- Source :
- Neural Plasticity, Vol 2021 (2021), Neural Plasticity
- Publication Year :
- 2021
- Publisher :
- Hindawi Limited, 2021.
-
Abstract
- Cochlear implantation is the first-line treatment for severe and profound hearing loss in children and adults. However, deaf patients with cochlear malformations or with cochlear nerve deficiencies are ineligible for cochlear implants. Meanwhile, the limited spatial selectivity and high risk of invasive craniotomy restrict the wide application of auditory brainstem implants. A noninvasive alternative strategy for safe and effective neuronal stimulation is urgently needed to address this issue. Because of its advantage in neural modulation over electrical stimulation, low-intensity ultrasound (US) is considered a safe modality for eliciting neural activity in the central auditory system. Although the neural modulation ability of low-intensity US has been demonstrated in the human primary somatosensory cortex and primary visual cortex, whether low-intensity US can directly activate auditory cortical neurons is still a topic of debate. To clarify the direct effects on auditory neurons, in the present study, we employed low-intensity US to stimulate auditory cortical neurons in vitro. Our data show that both low-frequency (0.8 MHz) and high-frequency (>27 MHz) US stimulation can elicit the inward current and action potentials in cultured neurons. c-Fos staining results indicate that low-intensity US is efficient for stimulating most neurons. Our study suggests that low-intensity US can excite auditory cortical neurons directly, implying that US-induced neural modulation can be a potential approach for activating the auditory cortex of deaf patients.
- Subjects :
- Article Subject
Primary Cell Culture
Action Potentials
Stimulation
Neurosciences. Biological psychiatry. Neuropsychiatry
Deafness
Auditory cortex
Somatosensory system
03 medical and health sciences
Mice
0302 clinical medicine
Pregnancy
otorhinolaryngologic diseases
Medicine
Auditory system
Animals
Humans
Ultrasonics
Cells, Cultured
030304 developmental biology
Auditory Cortex
Neurons
0303 health sciences
business.industry
Cochlear nerve
Cortical neurons
Electrophysiological Phenomena
Mice, Inbred C57BL
medicine.anatomical_structure
Visual cortex
Cochlear Implants
HEK293 Cells
Neurology
Female
Neurology (clinical)
Brainstem
business
Neuroscience
Proto-Oncogene Proteins c-fos
030217 neurology & neurosurgery
Research Article
RC321-571
Subjects
Details
- Language :
- English
- ISSN :
- 16875443 and 20905904
- Volume :
- 2021
- Database :
- OpenAIRE
- Journal :
- Neural Plasticity
- Accession number :
- edsair.doi.dedup.....e8e5d2091919d2463a7337d5cd76493d