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EUS-Guided Celiac Plexus Neurolysis for Pain due to Chronic Pancreatitis or Pancreatic Cancer Pain: A Meta-Analysis and Systematic Review

Authors :
William R. Brugge
Srinivas R. Puli
Matthew L. Bechtold
Jyotsna Batapati Krishna Reddy
Mainor R. Antillon
Source :
Digestive Diseases and Sciences. 54:2330-2337
Publication Year :
2009
Publisher :
Springer Science and Business Media LLC, 2009.

Abstract

The objective of this study was to evaluate the efficacy of EUS-guided CPN for pain relief in patients with chronic pancreatitis and pancreatic cancer. An initial search identified 1,439 reference articles, of which 130 relevant articles were selected and reviewed. Data was extracted from 8 studies (N = 283) for EUS-guided CPN for pain due to pancreatic cancer and nine studies for chronic pancreatitis (N = 376) which met the inclusion criteria. With EUS-guided CPN, the pooled proportion of patients with pancreatic cancer that showed pain relief was 80.12% (95% CI = 74.47-85.22). In patients with pain due to chronic pancreatitis, EUS-guided CPN provided pain relief in 59.45% (95% CI = 54.51-64.30). In conclusion, EUS-guided CPN offers a safe alternative technique for pain relief in patients with chronic pancreatitis or pancreatic cancer. In patients with pain due to chronic pancreatitis, better techniques or injected materials are needed to improve the response.

Details

ISSN :
15732568 and 01632116
Volume :
54
Database :
OpenAIRE
Journal :
Digestive Diseases and Sciences
Accession number :
edsair.doi.dedup.....e8fe9d47b3006f97f8421e01bb749e14
Full Text :
https://doi.org/10.1007/s10620-008-0651-x