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Cell-growth and migration inhibition of human mesothelioma cells induced by 3-O-Methylfunicone from Penicillium pinophilum and cisplatin
- Publication Year :
- 2012
-
Abstract
- Malignant pleural mesothelioma is a fatal malignancy linked to asbestos exposure. The main challenge for mesothelioma treatment is to go beyond the drug resistance, in particular against cisplatin (CDDP), one of the most used chemotherapeutic drug. 3-O-methylfunicone (OMF) is a metabolite produced by the fungus Penicillium pinophilum; its antiproliferative properties have been previously studied in vitro. Particularly, OMF is able to inhibit mesothelioma cell motility. To improve the effects of CDDP by-passing the resistance of mesothelioma cells to this drug, in the present study we investigated the combined treatment of OMF with CDDP respectively in an established mesothelioma cell line (NCI) and primary mesothelioma cells (Mest). As compared to the effect of single treatments, the combination of OMF and CDDP resulted in a stronger inhibition of NCI and Mest cell proliferation. OMF combination with CDDP was also able to affect the migratory ability of NCI and Mest cells by down-regulating αv and β5 expression and reducing metalloproteinase 2 (MMP-2) production. In addition, this association was effective in modulating VEGF gene expression. This finding highlights the possibility to use OMF and CDDP together to regulate angiogenesis and tumour progression in mesothelioma.
- Subjects :
- inorganic chemicals
Oncology
Mesothelioma
Vascular Endothelial Growth Factor A
medicine.medical_specialty
Angiogenesis
Motility
Integrin
Drug resistance
Biology
Cell Movement
Internal medicine
Cell Line, Tumor
Antineoplastic Combined Chemotherapy Protocols
medicine
3-O-methylfunicone
Humans
Pharmacology (medical)
Receptors, Vitronectin
RNA, Messenger
neoplasms
Cell Shape
Metalloproteinase
Migration
Cell Proliferation
Pharmacology
Cisplatin
Cell growth
Chemotaxis
Penicillium
medicine.disease
In vitro
respiratory tract diseases
Gene Expression Regulation, Neoplastic
Cell culture
Pyrones
Cancer research
Matrix Metalloproteinase 2
Human
medicine.drug
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....e90c3581e7e9d0c33d2a3960f2fbf9f3