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'Benifuuki' Extract Reduces Serum Levels of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Ligands Containing Apolipoprotein B: A Double-Blind Placebo-Controlled Randomized Trial
- Source :
- Nutrients, Vol 10, Iss 7, p 924 (2018), Nutrients, SC30201810090022, NARO成果DBa, OA, CC BY, Volume 10, Issue 7
- Publication Year :
- 2018
- Publisher :
- MDPI AG, 2018.
-
Abstract
- (1) Background: Arteriosclerosis is associated with high levels of low-density lipoprotein (LDL) cholesterol. O-methylated catechins in &ldquo<br />Benifuuki&rdquo<br />green tea are expected to reduce cholesterol levels, although there is limited research regarding this topic<br />(2) Methods: This trial evaluated 159 healthy volunteers who were randomized to receive ice cream containing a high-dose of &ldquo<br />extract including 676 mg of catechins (group H), a low-dose of &ldquo<br />extract including 322 mg of catechins (group L), or no &ldquo<br />extract (group C). Each group consumed ice cream (with or without extract) daily for 12 weeks, and their lipid-related parameters were compared<br />(3) Results: A significant reduction in the level of lectin-like oxidized LDL receptor-1 ligand containing ApoB (LAB) was detected in group H, compared to groups L and C. No significant differences between the three groups were detected in their levels of total cholesterol, triglycerides, and LDL cholesterol<br />(4) Conclusions: &ldquo<br />extract containing O-methylated catechins may help prevent arteriosclerosis.
- Subjects :
- Male
Lectin-like oxidized LDL receptor-1
Apolipoprotein B
Food Handling
O-methylated catechin
Catechols
030204 cardiovascular system & hematology
Pharmacology
Ligands
Camellia sinensis
law.invention
chemistry.chemical_compound
0302 clinical medicine
Randomized controlled trial
Japan
law
030212 general & internal medicine
Hypolipidemic Agents
Nutrition and Dietetics
biology
Arteriosclerosis
Middle Aged
Scavenger Receptors, Class E
Intention to Treat Analysis
Apolipoprotein B-100
Female
lipids (amino acids, peptides, and proteins)
Oxidation-Reduction
lcsh:Nutrition. Foods and food supply
Benifuuki
Hyperlipidemias
lcsh:TX341-641
Placebo
Article
03 medical and health sciences
Food Preferences
Double-Blind Method
medicine
Humans
Aged
Cholesterol
Plant Extracts
Ice Cream
dyslipidemia
Lectin
medicine.disease
Plant Leaves
LOX-1 ligand
chemistry
Dietary Supplements
biology.protein
Dyslipidemia
Biomarkers
Food Science
Lipoprotein
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Volume :
- 10
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....e918f5a41c3d22e929cb8b9c972fd1d2
- Full Text :
- https://doi.org/10.3390/nu10070924