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An alternative in vitro method for testing the potency of the polyvalent antivenom produced in Costa Rica
- Source :
- Toxicon; Volumen 26, Número 4, 1988, Kérwá, Universidad de Costa Rica, instacron:UCR
- Publication Year :
- 1988
-
Abstract
- The ability of several batches of polyvalent antivenom to neutralize indirect hemolytic activity of Bothrops asper venom was studied using a sensitive plate test. All samples of antivenom tested effectively neutralized this activity. A highly significant correlation was observed between neutralization of indirect hemolysis and neutralization of lethal activity. This simple and sensitive in vitro test could be used to monitor antibody levels in horses immunized to produce polyvalent antivenom. UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)
- Subjects :
- Costa Rica
Snake venom
Bothrops asper
Antivenom
Immunology
Venom
Drug Effects
In Vitro Techniques
Toxicology
Median lethal dose
complex mixtures
Hemolysis
Neutralization
Microbiology
Mice
Neutralization Tests
Crotalid Venoms
medicine
Potency
Animals
Horses
biology
Antivenins
medicine.disease
biology.organism_classification
In vitro
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Toxicon; Volumen 26, Número 4, 1988, Kérwá, Universidad de Costa Rica, instacron:UCR
- Accession number :
- edsair.doi.dedup.....e91fef365a0e26aba18076aed5479a10