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Relationship between response to inhaled salbutamol and methacholine bronchial provocation in children with suspected asthma
- Source :
- Pediatric pulmonology. 10(4)
- Publication Year :
- 1991
-
Abstract
- Fifty children (27 females, 23 males) ages 6-15 years who were referred for evaluation of suspected asthma had baseline FEV1 and FEF25-75 of greater than or equal to 80% and FEF50 greater than or equal to 70% of predicted values. All had these tests repeated on the same day, after inhaling salbutamol. On a subsequent day PC-20 (methacholine) was determined as an index of bronchial hyperreactivity (BH). Fourteen age-matched healthy children (6 females, 8 males) were studied in a similar manner. There was no significant relationship between the PC20 and the change in FEF25-75 or FEF50 following salbutamol. There was a negative correlation between the initial FEV1 (% predicted) and the percent change in FEV1 following salbutamol (P less than 0.01). An increase in FEV1 of greater than 6% occurred in 7/12 (58.3%) patients with PC20 less than or equal to 0.25 mg/mL (Group I); in 7/24 (29.2%) patients with PC20 = 0.26-2.0 mg/mL (Group II); in only 1/14 (7.1%) patients with PC20 greater than 2.1 mg/mL (Group III) and in none of those asymptomatic (control) children with PC20 greater than 8.0 mg/mL (Group IV). All subjects who had a change in FEV1 greater than 6% after salbutamol had a PC20 less than 8 mg/mL and this test detected the majority of patients with severe BH. However, although the sensitivity of the test was 100%, the predictive value was only 36%. We conclude that in the presence of a normal baseline FEV1 a change of greater than 6% following salbutamol inhalation is indicative of bronchial hyperreactivity.
- Subjects :
- Pulmonary and Respiratory Medicine
Male
Adolescent
medicine.drug_class
Provocation test
Bronchi
Asymptomatic
Bronchial Provocation Tests
Bronchodilator
Administration, Inhalation
medicine
Humans
Albuterol
Child
Methacholine Chloride
Asthma
Inhalation
business.industry
Respiration
Respiratory disease
respiratory system
medicine.disease
respiratory tract diseases
Anesthesia
Pediatrics, Perinatology and Child Health
Salbutamol
Methacholine
Female
medicine.symptom
business
circulatory and respiratory physiology
medicine.drug
Subjects
Details
- ISSN :
- 87556863
- Volume :
- 10
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Pediatric pulmonology
- Accession number :
- edsair.doi.dedup.....e92408ac64815df119a1137e4c80e4c4