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Temporary microglia-depletion after cosmic radiation modifies phagocytic activity and prevents cognitive deficits
- Source :
- Scientific reports, vol 8, iss 1, Scientific Reports, Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
- Publication Year :
- 2018
- Publisher :
- eScholarship, University of California, 2018.
-
Abstract
- Microglia are the main immune component in the brain that can regulate neuronal health and synapse function. Exposure to cosmic radiation can cause long-term cognitive impairments in rodent models thereby presenting potential obstacles for astronauts engaged in deep space travel. The mechanism/s for how cosmic radiation induces cognitive deficits are currently unknown. We find that temporary microglia depletion, one week after cosmic radiation, prevents the development of long-term memory deficits. Gene array profiling reveals that acute microglia depletion alters the late neuroinflammatory response to cosmic radiation. The repopulated microglia present a modified functional phenotype with reduced expression of scavenger receptors, lysosome membrane protein and complement receptor, all shown to be involved in microglia-synapses interaction. The lower phagocytic activity observed in the repopulated microglia is paralleled by improved synaptic protein expression. Our data provide mechanistic evidence for the role of microglia in the development of cognitive deficits after cosmic radiation exposure.
- Subjects :
- 0301 basic medicine
Male
Anaphylatoxin C5a
lcsh:Medicine
Complement receptor
Inbred C57BL
Mice
0302 clinical medicine
2.1 Biological and endogenous factors
Organic Chemicals
Aetiology
lcsh:Science
Receptor
Multidisciplinary
Behavior, Animal
Microglia
Phenotype
medicine.anatomical_structure
Neurological
Cytokines
Chemokines
Whole-Body Irradiation
Biology
Article
03 medical and health sciences
Immune system
Phagocytosis
Lysosome
medicine
Genetics
Acquired Cognitive Impairment
Animals
Cognitive Dysfunction
Scavenger receptor
Author Correction
Receptor, Anaphylatoxin C5a
Memory Disorders
Behavior
Animal
Macrophages
lcsh:R
Neurosciences
Brain Disorders
Mice, Inbred C57BL
Disease Models, Animal
030104 developmental biology
Membrane protein
nervous system
Synapses
Disease Models
lcsh:Q
Neuroscience
030217 neurology & neurosurgery
Cosmic Radiation
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Scientific reports, vol 8, iss 1, Scientific Reports, Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
- Accession number :
- edsair.doi.dedup.....e93a336ab7d6c43a51330dfd515580f6