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Susceptibility to leprosy is associated with PARK2 and PACRG
Susceptibility to leprosy is associated with PARK2 and PACRG
- Source :
- Nature. 427(6975)
- Publication Year :
- 2003
-
Abstract
- Leprosy is caused by Mycobacterium leprae and affects about 700,000 individuals each year1. It has long been thought that leprosy has a strong genetic component2, and recently we mapped a leprosy susceptibility locus to chromosome 6 region q25–q26 (ref. 3). Here we investigate this region further by using a systematic association scan of the chromosomal interval most likely to harbour this leprosy susceptibility locus. In 197 Vietnamese families we found a significant association between leprosy and 17 markers located in a block of approx. 80 kilobases overlapping the 5′ regulatory region shared by the Parkinson's disease gene PARK2 and the co-regulated gene PACRG. Possession of as few as two of the 17 risk alleles was highly predictive of leprosy. This was confirmed in a sample of 975 unrelated leprosy cases and controls from Brazil in whom the same alleles were strongly associated with leprosy. Variants in the regulatory region shared by PARK2 and PACRG therefore act as common risk factors for leprosy.
- Subjects :
- Ubiquitin-Protein Ligases
Polymorphism, Single Nucleotide
Leprosy
medicine
Humans
Genetic Predisposition to Disease
RNA, Messenger
Allele
Mycobacterium leprae
Gene
Alleles
Disease gene
Multidisciplinary
biology
Gene Expression Profiling
Microfilament Proteins
Chromosome
Chromosome Mapping
Proteins
biology.organism_classification
medicine.disease
Phenotype
Haplotypes
Vietnam
Case-Control Studies
Risk allele
Immunology
Susceptibility locus
Chromosomes, Human, Pair 6
Brazil
Molecular Chaperones
Subjects
Details
- ISSN :
- 14764687
- Volume :
- 427
- Issue :
- 6975
- Database :
- OpenAIRE
- Journal :
- Nature
- Accession number :
- edsair.doi.dedup.....e94f70552f3fdf5f14d64afc355e9a5a