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COHORT PROFILE: The Complications of Long-Term Antiretroviral Therapy study in Uganda (CoLTART), a prospective clinical cohort
- Source :
- AIDS Research and Therapy, Vol 14, Iss 1, Pp 1-12 (2017), AIDS Research and Therapy
- Publication Year :
- 2017
- Publisher :
- BMC, 2017.
-
Abstract
- Background Antiretroviral therapy (ART) improves the survival and quality of life of HIV-positive individuals, but the effects of long-term ART use do eventually manifest. The Complications of Long-Term Antiretroviral Therapy cohort study in Uganda (CoLTART) was established to investigate the metabolic and renal complications of long-term ART use among Ugandan adults. We describe the CoLTART study set-up, aims, objectives, study methods, and also report some preliminary cross–sectional study enrolment metabolic and renal complications data analysis results. Methods HIV-positive ART naïve and experienced adults (18 years and above) in Uganda were enrolled. Data on demographic, dietary, medical, social economic and behaviour was obtained; and biophysical measurements and a clinical examination were undertaken. We measured: fasting glucose and lipid profiles, renal and liver function tests, full blood counts, immunology, virology and HIV drug resistance testing. Plasma samples were stored for future studies. Results Between July 2013 and October 2014, we enrolled 1095 individuals, of whom 964 (88.0%) were ART experienced (6 months or more), with a median of 9.4 years (IQR 7.0–9.9) on ART. Overall, 968 (88.4%) were aged 35 years and above, 711 (64.9%) were females, 608 (59.6%) were or had ever been on a Tenofovir ART regimen and 236 (23.1%) on a Protease Inhibitor (PI) regimen. There were no differences in renal dysfunction between patients on Tenofovir and Non-Tenofovir containing ART regimens. Patients on PI regimens had higher total cholesterol, lower high density lipoprotein, higher low density lipoprotein, higher triglycerides, and a high atherogenic index for plasma than the non-PI regimen, p = 0.001 or
- Subjects :
- Adult
Male
lcsh:Immunologic diseases. Allergy
medicine.medical_specialty
Adolescent
030231 tropical medicine
HIV Infections
Physical examination
Cohort profile
Disease
Renal complications
Young Adult
03 medical and health sciences
0302 clinical medicine
Quality of life
Antiretroviral Therapy, Highly Active
Virology
Internal medicine
medicine
Humans
Uganda
Pharmacology (medical)
Prospective Studies
030212 general & internal medicine
Aged
Aged, 80 and over
medicine.diagnostic_test
business.industry
Research
HIV-Associated Lipodystrophy Syndrome
HIV
Middle Aged
Metabolic abnormalities
Antiretroviral therapy
Regimen
Cross-Sectional Studies
Anti-Retroviral Agents
Cardiovascular Diseases
Cohort
Physical therapy
Molecular Medicine
Female
Kidney Diseases
lcsh:RC581-607
Liver function tests
business
HIV drug resistance
Cohort study
Subjects
Details
- Language :
- English
- ISSN :
- 17426405
- Database :
- OpenAIRE
- Journal :
- AIDS Research and Therapy, Vol 14, Iss 1, Pp 1-12 (2017), AIDS Research and Therapy
- Accession number :
- edsair.doi.dedup.....e953c07a5b1bdbd5aa2a7b1604a27ed7