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Antigen-specific T regulatory-1 cells are associated with immunosuppression in a chronic helminth infection (onchocerciasis)
- Source :
- Microbes and Infection. 4:1291-1300
- Publication Year :
- 2002
- Publisher :
- Elsevier BV, 2002.
-
Abstract
- Different mechanisms underlie the phenomenon of peripheral tolerance. Recently, a new subset of CD4+ T cells, called T regulatory-1 (Tr1) cells, was described which show suppressor functions in vitro and in vivo and are characterized by a predominant production of IL-10 and/or TGF-β. Tr1 cells have so far been generated experimentally in an IL-10-rich environment and hold promise for exploitation in the suppression of alloreactions and inflammatory or allergic dispositions. However, these cells have not been characterized in infectious diseases. Here we show that in the chronic helminth infection onchocerciasis (river blindness), where patients have relatively little sign of dermatitis despite the presence of millions of small worms in the skin, T cells can be obtained which bear characteristics of Tr1 cells, producing no IL-2 or IL-4 but substantial amounts of IL-10, variable amounts of IL-5, and some IFN-γ. These cells display elevated amounts of CTLA-4 after stimulation and are able to inhibit other T cells in coculture, in contrast to Th1 and Th2 clones. This is the first time that this type of suppressor T cell has been cloned as naturally occurring during an infectious disease.
- Subjects :
- CD4-Positive T-Lymphocytes
Immunoconjugates
medicine.medical_treatment
Immunology
Biology
Onchocerciasis
Microbiology
Immune tolerance
Abatacept
Interferon-gamma
Antigens, CD
Immune Tolerance
medicine
Animals
Humans
CTLA-4 Antigen
Cells, Cultured
Immunosuppression Therapy
Interleukin-13
Peripheral tolerance
Immunosuppression
T lymphocyte
Natural killer T cell
Antigens, Differentiation
Virology
In vitro
Clone Cells
Interleukin-10
Onchocerca volvulus
Infectious Diseases
Cytokine
Infectious disease (medical specialty)
Antigens, Helminth
CD4 Antigens
Chronic Disease
Cytokines
Interleukin-2
Interleukin-5
Subjects
Details
- ISSN :
- 12864579
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Microbes and Infection
- Accession number :
- edsair.doi.dedup.....e972b1406300386afedb6d3208f75454