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Prediction of hepatocellular carcinoma in Hepatitis C patients with advanced fibrosis after sustained virologic response
- Source :
- Clinics and Research in Hepatology and Gastroenterology, Clinics and Research in Hepatology and Gastroenterology, 2022, 46 (6), pp.101923. ⟨10.1016/j.clinre.2022.101923⟩, Clinics and Research in Hepatology and Gastroenterology, Elsevier, 2022, pp.101923. ⟨10.1016/j.clinre.2022.101923⟩
- Publication Year :
- 2022
- Publisher :
- HAL CCSD, 2022.
-
Abstract
- International audience; Background & Aims: Prediction of hepatocellular carcinoma (HCC) occurrence in patients with chronic hepatitis C (HCV) who achieved a sustained virological response (SVR) after direct acting antivirals (DAAs) remains challenging.Methods: Among HCC-free HCV patients with advanced fibrosis enrolled in the ANRS CO22 HEPATHER cohort who achieved SVR 12 weeks after treatment with DAAs, HCC predictive models were developed using Cox multivariable regression. The derived score was externally validated in a large Egyptian cohort. Our main outcome was the HCC-free survival.Results: During follow-up (median 3.05 years), 153 out of 3531 patients developed a HCC. Main variables associated with HCC occurrence were: male gender, HCV genotype 3, esophageal varices, albumin < 40 g/L, total bilirubin >11 µmol/L and hypercholesterolemia before DAA initiation, together with age > 58 years, FIB-4 index ≥3.25 evaluated at SVR. A score was established allowing the stratification of patients by high (score ≥ 12/22), intermediate (7 ≤ score
- Subjects :
- Liver Cirrhosis
Male
Carcinoma, Hepatocellular
Hepatology
Sustained Virologic Response
Hepatitis C virus
Liver Neoplasms
Gastroenterology
[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
[SDV.CAN]Life Sciences [q-bio]/Cancer
Hepacivirus
Hepatitis C, Chronic
Middle Aged
Antiviral Agents
Hepatitis C
Risk factors
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Humans
Risk score
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
HCC
ComputingMilieux_MISCELLANEOUS
Subjects
Details
- Language :
- English
- ISSN :
- 22107401 and 2210741X
- Database :
- OpenAIRE
- Journal :
- Clinics and Research in Hepatology and Gastroenterology, Clinics and Research in Hepatology and Gastroenterology, 2022, 46 (6), pp.101923. ⟨10.1016/j.clinre.2022.101923⟩, Clinics and Research in Hepatology and Gastroenterology, Elsevier, 2022, pp.101923. ⟨10.1016/j.clinre.2022.101923⟩
- Accession number :
- edsair.doi.dedup.....e9755067cfdf7e5e0f0659a66891f318
- Full Text :
- https://doi.org/10.1016/j.clinre.2022.101923⟩