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Apolipoprotein e4 allele and the risk of CAD death in type 2 diabetes mellitus with ischaemia electrocardiographic change
- Source :
- Diabetes research and clinical practice. 68(3)
- Publication Year :
- 2003
-
Abstract
- The presence of apolipoprotein (Apo) e4 allele is reported to be associated with the increased risk of coronary artery disease (CAD), as well as the impairment of endothelium-dependent arterial dilation in type 2 diabetes mellitus. Therefore, we hypothesized that Apo e4 allele increases the death risk from coronary artery disease in type 2 diabetes with ischaemia electrocardiographic change. From January 1993 to December 1999, 46 type 2 diabetic patients with e4/4 or e4/3, 96 with e3/3 and 45 with e2/2 or e3/2 genotypes were recruited. All subjects were unrelated elderly type 2 diabetic patients with ischaemia electrocardiographic change, aged 60-87 years, and their cardiac function were all the class I stage at their time of enrollment. A follow-up study of 3-10 years was undergone. The results are as follows: At baseline, serum total cholesterol and low-density lipoprotein (LDL) cholesterol concentrations were higher in subjects with e4/3 or e4/4 than in subjects with e2/2 or e3/2 (p
- Subjects :
- Apolipoprotein E
Male
Risk
medicine.medical_specialty
Apolipoprotein B
Endocrinology, Diabetes and Metabolism
Population
Apolipoprotein E4
Myocardial Ischemia
Type 2 diabetes
Coronary Artery Disease
Coronary artery disease
chemistry.chemical_compound
Electrocardiography
Endocrinology
Apolipoproteins E
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Humans
Genetic Predisposition to Disease
education
Alleles
Aged
Aged, 80 and over
education.field_of_study
biology
Cholesterol
business.industry
Type 2 Diabetes Mellitus
General Medicine
Middle Aged
medicine.disease
chemistry
Diabetes Mellitus, Type 2
biology.protein
Cardiology
Female
business
Diabetic Angiopathies
Subjects
Details
- ISSN :
- 01688227
- Volume :
- 68
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Diabetes research and clinical practice
- Accession number :
- edsair.doi.dedup.....e99a67363bb5055e2ff61b126cd2aeda