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The Role of Cytokines in the Fibrotic Responses in Crohn’s Disease
- Source :
- Frontiers in Medicine, Vol 4 (2017), CONICET Digital (CONICET), Consejo Nacional de Investigaciones Científicas y Técnicas, instacron:CONICET, SEDICI (UNLP), Universidad Nacional de La Plata, instacron:UNLP, Frontiers in Medicine
- Publication Year :
- 2017
- Publisher :
- Frontiers Media SA, 2017.
-
Abstract
- Crohn's disease is an idiopathic disorder of the gut thought to be caused by a combination of environmental and genetic factors in susceptible individuals. It is characterized by chronic transmural inflammation of the terminal ileum and colon, with typical transmural lesions. Complications, including fibrosis, mean that between 40 and 70% of patients require surgery in the first 10 years after diagnosis. Presently, there is no evidence that the current therapies which dampen inflammation modulate or reverse intestinal fibrosis. In this review, we focus on cytokines that may lead to fibrosis and stenosis and the contribution of experimental models for understanding and treatment of gut fibrosis.<br />Instituto de Estudios Inmunológicos y Fisiopatológicos
- Subjects :
- Crohn’s disease
0301 basic medicine
Disease
Gastroenterology
Extracellular matrix
0302 clinical medicine
Fibrosis
FIBROSIS
Idiopathic disorder
lcsh:R5-920
Crohn's disease
purl.org/becyt/ford/3.1 [https]
Chronic inflammation
General Medicine
3. Good health
Medicina Básica
medicine.anatomical_structure
Strictures
Medicine
Cytokines
purl.org/becyt/ford/3 [https]
030211 gastroenterology & hepatology
medicine.symptom
lcsh:Medicine (General)
STRICTURES
medicine.medical_specialty
CIENCIAS MÉDICAS Y DE LA SALUD
Mini Review
Inmunología
EXTRACELLULAR MATRIX
Inflammation
03 medical and health sciences
Internal medicine
medicine
Terminal ileum
CROHN´S DISEASE
FIBROSTENOSIS
CHRONIC INFLAMATION
Ciencias Exactas
business.industry
CYTOKINES
medicine.disease
Stenosis
030104 developmental biology
Immunology
Fibrostenosis
business
Subjects
Details
- ISSN :
- 2296858X
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Frontiers in Medicine
- Accession number :
- edsair.doi.dedup.....e99e699ce54a330c5a4e40fe74fe34d1