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Remarkable enantioselectivity enhancement of the extractors with nonaxial chirality in liquid–liquid extraction of underivatized amino acids by introducing t ‐butyl group
- Source :
- Chirality. 34:999-1007
- Publication Year :
- 2022
- Publisher :
- Wiley, 2022.
-
Abstract
- A class of carbonyl extractors, (R)-3, (R)-4, and (R)-5, with nonaxial chirality containing asymmetric carbons has been synthesized and studied for their efficiencies in enantioselective liquid-liquid extraction for underivatized amino acids. The bulky t-butyl ketone extractors, (R)-4 and (R)-5, showed the stereoselectivities ranging 5.4-9.4 of l/d ratio much better than those of the aldehyde extractor, (R)-3, ranging 2.4-5.2. The imine formation rates and yields of the t-butyl ketones were not significantly affected by their bulkiness and even in the absence of resonance-assisted hydrogen bond. This work confirms that a bulky t-butyl ketone can be a good choice in the development of an extractor not only with axial chirality but also with nonaxial chirality for the enantioselective extraction of unprotected amino acids.
Details
- ISSN :
- 1520636X and 08990042
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Chirality
- Accession number :
- edsair.doi.dedup.....e9a1729f6712d220dedcb0ca66ede9ef