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One-Pot Synthesis of 2-Pyridones via Chemo- and Regioselective Tandem Blaise Reaction of Nitriles with Propiolates
- Source :
- The Journal of Organic Chemistry. 74:7556-7558
- Publication Year :
- 2009
- Publisher :
- American Chemical Society (ACS), 2009.
-
Abstract
- The Blaise reaction intermediate, generated in situ from Reformatsky reagent and nitrile, reacted with propiolates in a chemo- and regioselective manner to afford 2-pyridone derivatives in good to excellent yields.
- Subjects :
- Molecular Structure
Nitrile
Pyridones
Chemistry
Organic Chemistry
One-pot synthesis
Regioselectivity
Stereoisomerism
Reaction intermediate
Combinatorial chemistry
Zinc
chemistry.chemical_compound
Cascade reaction
Alkynes
Reagent
Nitriles
Organometallic Compounds
Organic chemistry
Blaise reaction
Propionates
Reformatsky reaction
Subjects
Details
- ISSN :
- 15206904 and 00223263
- Volume :
- 74
- Database :
- OpenAIRE
- Journal :
- The Journal of Organic Chemistry
- Accession number :
- edsair.doi.dedup.....e9a3cdbde38fbb2906a3b590c52a282c
- Full Text :
- https://doi.org/10.1021/jo901642t