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Retinol-binding protein 4 is closely correlated to blood pressure level and E/A in untreated essential hypertension patients
- Source :
- Annals of palliative medicine. 8(5)
- Publication Year :
- 2019
-
Abstract
- Hypertension, a common chronic disease, is a leading cause of death and other cardiovascular diseases. Recent studies show that an inflammatory factor named retinol binding protein 4 (RBP4) was increased with cardiovascular diseases. However, the relationship between RBP4 and hypertension in patients remains unclear.The study cohort was composed of patients with essential hypertension (EH) and healthy control (HC) subjects from the Second Affiliated Hospital of Nanjing Medical University [2017-2019]. The levels of RBP4 and echocardiography were compared in the current study. Statistical differences between two groups were analyzed using unpaired Student's t-tests and the correlation between the two variables adopts Pearson correlation analysis. SPSS 23.0 was used for all statistical analysis.Analysis of patient plasma samples revealed that RBP4 in EH group was greater than HC group (P0.05). The area under the ROC curve was 0.717. Specificity and sensitivity were 80.4% and 60.8%, respectively. RBP4 had positive correlation with left ventricular systolic diameter (LVDs), interventricular septal thickness (IVS) and left ventricular posterior wall thickness (LVPW), negative correlation with left ventricular shortening fraction (FS) and ejection fraction (EF) (P0.05), and no correlation with left ventricular end-diastolic diameter (LVDd) (P0.05). RBP4 was closely related with E/A, evaluation method of left ventricular diastolic function, in patients with EH.RBP4 levels are closely correlated with blood pressure (BP) levels and might be involved in the regulation of left ventricular diastolic function in patients with EH.
- Subjects :
- 0301 basic medicine
Adult
Male
medicine.medical_specialty
030209 endocrinology & metabolism
Blood Pressure
Essential hypertension
Gastroenterology
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
In patient
Correlation test
Cause of death
Advanced and Specialized Nursing
Retinol binding protein 4
biology
business.industry
Blood pressure level
Middle Aged
medicine.disease
030104 developmental biology
Anesthesiology and Pain Medicine
Blood pressure
Cohort
biology.protein
Female
Essential Hypertension
business
Retinol-Binding Proteins, Plasma
Subjects
Details
- ISSN :
- 22245839
- Volume :
- 8
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Annals of palliative medicine
- Accession number :
- edsair.doi.dedup.....e9a531ebad2d8b01b048b0a9351a0182