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Discovery of Populusone, a Skeletal Stimulator of Umbilical Cord Mesenchymal Stem Cells from Populus euphratica Exudates
- Source :
- Organic letters. 21(6)
- Publication Year :
- 2019
-
Abstract
- Populusone (1), a cembrane-type macrocyclic trinorditerpenoid, was isolated from the exudates of Populus euphratica and shown to have an unprecedented carbon skeleton, The structure was identified using spectroscopic methods and X-ray crystallography. A possible pathway for the biosynthesis of 1 was proposed. Populusone (10 μM) was found to promote proliferation and differentiation of umbilical cord derived mesenchymal stem cells into keratinocyte like cells.
- Subjects :
- Cellular differentiation
Carbon skeleton
010402 general chemistry
01 natural sciences
Biochemistry
Umbilical cord
Umbilical Cord
chemistry.chemical_compound
Biosynthesis
medicine
Physical and Theoretical Chemistry
biology
Molecular Structure
010405 organic chemistry
Organic Chemistry
Mesenchymal stem cell
Cell Differentiation
Mesenchymal Stem Cells
biology.organism_classification
0104 chemical sciences
Cell biology
medicine.anatomical_structure
Populus
chemistry
Keratinocyte
Populus euphratica
Subjects
Details
- ISSN :
- 15237052
- Volume :
- 21
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Organic letters
- Accession number :
- edsair.doi.dedup.....e9ac443d41844ec8324ae7999d372a32