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Suppression of Ehrlich carcinoma growth by cobra venom factor
Suppression of Ehrlich carcinoma growth by cobra venom factor
- Source :
- Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections. 470(1)
- Publication Year :
- 2016
-
Abstract
- Cobra venom factor (CVF) depletes the complement system of the blood by forming stable convertase C3/C5 of the alternative pathway. We found that CVF from the Thailand cobra venom slows down the growth of subcutaneous Ehrlich carcinoma (EC) in mice at a dose of 1.7 nmol/g. Previously, we described a similar effect for the nerve growth factor (NGF) from the venom of this cobra. However, these factors did not exhibit either synergy or additive effect. On the contrary, they neutralized the antitumor effect of each other when they were administered simultaneously. Therefore, on the one hand, the NGF antitumor effect against EC manifests itself under the conditions of inflammation, and normal functioning of the complement system is necessary for this effect to occur. On the other hand, suppression of the humoral immune system leads to a slowdown of the EC growth, but administration of NGF prevents this.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Cell Survival
Inflammation
Venom
Cobra
complex mixtures
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Mice
Immune system
Internal medicine
Cell Line, Tumor
Antineoplastic Combined Chemotherapy Protocols
Nerve Growth Factor
medicine
Animals
Carcinoma, Ehrlich Tumor
computer.programming_language
Cell Proliferation
Elapid Venoms
General Immunology and Microbiology
Dose-Response Relationship, Drug
Chemistry
Cell growth
Body Weight
General Medicine
Complement system
Tumor Burden
Mice, Inbred C57BL
030104 developmental biology
Endocrinology
Nerve growth factor
Complement Inactivating Agents
Treatment Outcome
Alternative complement pathway
medicine.symptom
General Agricultural and Biological Sciences
computer
Subjects
Details
- ISSN :
- 16083105
- Volume :
- 470
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections
- Accession number :
- edsair.doi.dedup.....e9eb924844c3fcb0c2135a9c7c9bc589