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Risk estimation for biliary tract cancer: Development and validation of a prognostic score

Authors :
Sarah Berhane
Philip J. Johnson
Marianne Sinn
Zeynep Balta
Mareike Fischer
Tobias J. Weismüller
Christian P. Strassburg
Arndt Vogel
Martina Kottas
Tanja Reineke-Plaaß
Arndt Weinmann
Nora Schweitzer
Michael P. Manns
Hüseyin Bektas
Maria A. Gonzalez-Carmona
Martha M. Kirstein
Source :
LIVER INTERNATIONAL
Publication Year :
2017

Abstract

Background & Aims Biliary tract cancer is a rare tumour entity characterized by a poor prognosis. We aimed to identify prognostic factors and create a prognostic score to estimate survival. Methods Clinical data of the training set, consisting of 569 patients treated from 2000 to 2010 at Hannover Medical School, were analysed. A prognostic model defining three prognostic risk groups was derived from Cox regression analyses. The score was applied and validated in an independent cohort of 557 patients from four different German centres. Results Median overall survival (OS) was 14.5 months. If complete resection was performed, the patients had a significantly improved OS (23.9 months; n=242) as compared to patients with non-resectable tumours (9.1 months; n=329, P

Details

ISSN :
14783231
Volume :
37
Issue :
12
Database :
OpenAIRE
Journal :
Liver international : official journal of the International Association for the Study of the Liver
Accession number :
edsair.doi.dedup.....ea026955b5f655289d4d9ecd6436e111