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Role of Mitochondrial Dysfunction in the Pathology of Amyloid-β
- Source :
- Journal of Alzheimer's Disease. 78:505-514
- Publication Year :
- 2020
- Publisher :
- IOS Press, 2020.
-
Abstract
- Mitochondrial dysfunction has been widely reported in several neurodegenerative disorders, including in the brains of patients with Alzheimer’s disease (AD), Parkinson’s disease, and Huntington disease. An increasing number of studies have implicated altered glucose and energy metabolism in patients with AD. There is compelling evidence of abnormalities in some of the key mitochondrial enzymes involved in glucose metabolism, including the pyruvate dehydrogenase and α-ketoglutarate dehydrogenase complexes, which play a great significance role in the pathogenesis of AD. Changes in some of the enzyme activities of the mitochondria found in AD have been linked with the pathology of amyloid-β (Aβ). This review highlights the role of mitochondrial function in the production and clearance of Aβ and how the pathology of Aβ leads to a decrease in energy metabolism by affecting mitochondrial function.
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
Metabolic Clearance Rate
Dehydrogenase
Disease
Mitochondrion
Carbohydrate metabolism
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Alzheimer Disease
medicine
Animals
Humans
chemistry.chemical_classification
Amyloid beta-Peptides
business.industry
General Neuroscience
Brain
General Medicine
Pyruvate dehydrogenase complex
Mitochondria
Psychiatry and Mental health
Clinical Psychology
030104 developmental biology
Enzyme
chemistry
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
Function (biology)
Subjects
Details
- ISSN :
- 18758908 and 13872877
- Volume :
- 78
- Database :
- OpenAIRE
- Journal :
- Journal of Alzheimer's Disease
- Accession number :
- edsair.doi.dedup.....ea2d99d34ea0ef8480cc97e2508f8f95