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Inhaled corticosteroid use is associated with increased circulating T regulatory cells in children with asthma
- Source :
- Clinical and Molecular Allergy, Clinical and Molecular Allergy : CMA
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- Background T regulatory (Treg) cells are important in balancing immune responses and dysregulation of Treg cells has been implicated in the pathogenesis of multiple disease states including asthma. In this study, our primary aim was to determine Treg cell frequency in the peripheral blood of children with and without asthma. The secondary aim was to explore the association between Treg cell frequency with allergen sensitization, disease severity and medication use. Methods Peripheral blood mononuclear cells from healthy control subjects (N = 93) and asthmatic children of varying disease severity (N = 66) were characterized by multi-parameter flow cytometry. Results Our findings demonstrate that children with asthma had a significantly increased frequency of Treg cells compared to children without asthma. Using a multivariate model, increased Treg cell frequency in children with asthma was most directly associated with inhaled corticosteroid use, and not asthma severity, allergic sensitization, or atopic status of the asthma. Conclusion We conclude that low dose, local airway administration of corticosteroids is sufficient to impact the frequency of Treg cells in the peripheral blood. These data highlight the importance of considering medication exposure when studying Treg cells and suggest inhaled corticosteroid use in asthmatics may improve disease control through increased Treg cell frequency.
- Subjects :
- Allergy
Immunology
chemical and pharmacologic phenomena
Disease
Allergic sensitization
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Immune system
medicine
Immunology and Allergy
T regulatory cell
Interleukin-7 receptor
Molecular Biology
030304 developmental biology
Asthma
0303 health sciences
Inhaled corticosteroids
business.industry
Research
FOXP3
hemic and immune systems
medicine.disease
respiratory tract diseases
3. Good health
CD127
Foxp3
business
030215 immunology
Subjects
Details
- ISSN :
- 14767961
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Clinical and Molecular Allergy
- Accession number :
- edsair.doi.dedup.....ea47d721d6f2df5bd39d40e1cad46311
- Full Text :
- https://doi.org/10.1186/1476-7961-11-1