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Amiodarone treatment in atrial fibrillation and the risk of incident cancers: A nationwide observational study
- Source :
- Rasmussen, P V, Dalgaard, F, Gislason, G H, Torp-Pedersen, C, Piccini, J, D'Souza, M, Ruwald, M H, Pallisgaard, J L & Hansen, M L 2020, ' Amiodarone treatment in atrial fibrillation and the risk of incident cancers : a nationwide observational study ', Heart Rhythm, vol. 17, no. 4, pp. 560-566 . https://doi.org/10.1016/j.hrthm.2019.11.025
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Background: In observational studies, case reports, and animal studies, amiodarone has been associated with incident cancer. Objective: The purpose of this study was to examine whether a dose–response relationship between amiodarone use and the risk of cancer could be ascertained in a large nationwide study cohort. Methods: Using nationwide registers, we included all Danish patients with atrial fibrillation (AF) treated with amiodarone from 1996 to 2014. Exposure was defined both by categories and as a continuous variable of the cumulative defined daily doses (cDDDs) of amiodarone. The associations between amiodarone cDDD and incident cancer, as well as organ-specific types of cancer (skin, liver, lung), were estimated using multivariable Cox regression models and reported as hazard ratios (HR) with 95% confidence intervals (CI) and using cubic restricted spline plots. Results: We included 18,503 patients with a median follow-up time of 8.1 years (interquartile range [IQR] 4.3–12.4). Median age was 70 years (IQR 63–77). A total of 2974 individuals developed cancer during follow-up. We found no association between increasing amiodarone exposure (cDDD 181–400 and cDDD >400) and the hazard of incident cancer (HR 0.95; 95% CI 0.87–1.04; and HR 1.01; 95% CI 0.92–1.10) with reference to patients with cDDD
- Subjects :
- Adult
Male
medicine.medical_specialty
Epidemiology
Denmark
Amiodarone
030204 cardiovascular system & hematology
Risk Assessment
03 medical and health sciences
0302 clinical medicine
Risk Factors
Interquartile range
Neoplasms
Physiology (medical)
Internal medicine
Atrial Fibrillation
medicine
Humans
030212 general & internal medicine
Cancer
Aged
Retrospective Studies
Aged, 80 and over
Proportional hazards model
Cumulative dose
business.industry
Incidence
Hazard ratio
Middle Aged
medicine.disease
Atrial fibrillation
Confidence interval
Population Surveillance
Cohort
Female
Cardiology and Cardiovascular Medicine
business
Anti-Arrhythmia Agents
Arrhythmia
medicine.drug
Subjects
Details
- ISSN :
- 15475271
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Heart Rhythm
- Accession number :
- edsair.doi.dedup.....ea49ccfd12f1303b532928eb6a5e8eea
- Full Text :
- https://doi.org/10.1016/j.hrthm.2019.11.025