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A novel Alzheimer disease locus located near the gene encoding tau protein

Authors :
Jun, G
Ibrahim-Verbaas, CA
Vronskaya, M
Lambert, J-C
Chung, J
Naj, AC
Kunkle, BW
Wang, L-S
Bis, JC
Bellenguez, C
Harold, D
Lunetta, KL
Destefano, AL
Grenier-Boley, B
Sims, R
Beecham, GW
Smith, AV
Chouraki, V
Hamilton-Nelson, KL
Ikram, MA
Fievet, N
Denning, N
Martin, ER
Schmidt, H
Kamatani, Y
Dunstan, ML
Valladares, O
Laza, AR
Zelenika, D
Ramirez, A
Foroud, TM
Choi, S-H
Boland, A
Becker, T
Kukull, WA
Van Der Lee, SJ
Pasquier, F
Cruchaga, C
Beekly, D
Fitzpatrick, AL
Hanon, O
Gill, M
Barber, R
Gudnason, V
Campion, D
Love, S
Bennett, DA
Amin, N
Berr, C
Tsolaki, Magda
Buxbaum, JD
Lopez, OL
Deramecourt, V
Fox, NC
Cantwell, LB
Tárraga, L
Dufouil, C
Hardy, J
Crane, PK
Eiriksdottir, G
Hannequin, D
Clarke, R
Evans, D
Mosley, TH
Letenneur, L
Brayne, C
Maier, W
De Jager, P
Emilsson, V
Dartigues, J-F
Hampel, H
Kamboh, MI
De Bruijn, RFAG
Tzourio, C
Pastor, P
Larson, EB
Rotter, JI
O'Donovan, MC
Montine, TJ
Nalls, MA
Mead, S
Reiman, EM
Jonsson, PV
Holmes, C
St George-Hyslop, PH
Boada, M
Passmore, P
Wendland
Schmidt, R
Morgan, K
Winslow, AR
Powell, JF
Carasquillo, M
Younkin, SG
Jakobsdóttir, J
Kauwe, JSK
Wilhelmsen, KC
Rujescu, D
Nöthen, MM
Hofman, A
Jones, L
IGAP Consortium
Haines, JL
Psaty, BM
Van Broeckhoven, C
Holmans, P
Launer, LJ
Mayeux, R
Lathrop, M
Goate, AM
Escott-Price, V
Seshadri, S
Pericak-Vance, MA
Amouyel, P
Williams, J
Van Duijn, CM
Schellenberg, GD
Farrer, LA
Chouraki, V [0000-0002-4698-1794]
Amouyel, P [0000-0001-9088-234X]
Apollo - University of Cambridge Repository
Publication Year :
2019
Publisher :
Apollo - University of Cambridge Repository, 2019.

Abstract

APOE ɛ4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the International Genomics of Alzheimer's Project (IGAP) Consortium in APOE ɛ4+ (10 352 cases and 9207 controls) and APOE ɛ4- (7184 cases and 26 968 controls) subgroups as well as in the total sample testing for interaction between a single-nucleotide polymorphism (SNP) and APOE ɛ4 status. Suggestive associations (P

Subjects

Subjects :
Alzheimer Disease
Apolipoprotein E4
Humans
tau Proteins
Polymorphism, Single Nucleotide
Chromosomes, Human, Pair 17
Genome-Wide Association Study

Details

Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....ea4dfc181ad7b04eb3f3078d1e74e920
Full Text :
https://doi.org/10.17863/cam.40189
Full Text Access
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