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A lanthanide-based magnetic nanosensor as an erasable and visible platform for multi-color point-of-care detection of multiple targets and the potential application by smartphone
- Source :
- Journal of materials chemistry. B. 7(5)
- Publication Year :
- 2020
-
Abstract
- The sensitive, selective and point-of-care detection of dipicolinic acid (DPA) is of great significance for the prevention of the anthrax virus and the containment of bioterrorism. In this work, a multi-color fluorescent nanoprobe composed of lanthanides and magnetic nanoparticles (Fe3O4@CePO4:Tb-EDTA-Eu) has been designed, in which the portion of Fe3O4@CePO4:Tb can be used as the internal stable signal of green fluorescence, while the EDTA-Eu part can be used as the sensitive reaction signal for monitoring DPA. Upon the addition of DPA, the red fluorescence of Eu3+ ions is significantly enhanced, while the fluorescent color of the nanoprobes can change from green to red (such as yellow-green, orange-yellow and orange-red), achieving visual multi-color fluorescent detection even by the naked eye. By using the magnetic separation method, the composites can be easily purified for point-of-care testing. More importantly, the nanoprobe fixed test pieces enable real-time analysis of DPA by using an easy-to-access color-scanning application on a smartphone. Furthermore, the fluorescence intensity can be quenched by the addition of Cu2+, which leads to a rewritable nanosensor and can be used in the detection of cysteine (Cys) with high sensitivity. With the addition of Cys, this erasable nano detection platform can also display the original multi-color visual point-of-care detection. With further optimization, this new type of multi-color fluorescent assay is promising in point-of-care clinics for multi-target diagnostics.
- Subjects :
- Materials science
Point-of-Care Systems
Biomedical Engineering
Magnetic separation
Nanoprobe
Biological Warfare Agents
02 engineering and technology
010402 general chemistry
01 natural sciences
Signal
Lanthanoid Series Elements
Anthrax
chemistry.chemical_compound
Magnetics
Nanosensor
Humans
General Materials Science
Picolinic Acids
Fluorescent Dyes
business.industry
fungi
food and beverages
General Chemistry
General Medicine
021001 nanoscience & nanotechnology
Dipicolinic acid
Fluorescence
Bioterrorism
0104 chemical sciences
chemistry
Optoelectronics
Magnetic nanoparticles
Nanoparticles
Naked eye
Smartphone
0210 nano-technology
business
Subjects
Details
- ISSN :
- 20507518
- Volume :
- 7
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of materials chemistry. B
- Accession number :
- edsair.doi.dedup.....ea504a4495689794b57b000e8d73fd89