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Octreotide induced prolongation of colonic transit increases faecal anaerobic bacteria, bile acid metabolising enzymes, and serum deoxycholic acid in patients with acromegaly
- Source :
- Gut. 54:630-635
- Publication Year :
- 2005
- Publisher :
- BMJ, 2005.
-
Abstract
- Background: Acromegalic patients have slow colonic transit, increased rates of deoxycholic acid formation, and an increased prevalence of cholesterol gall stones, especially during long term octreotide treatment. However, the effects of this prolonged large bowel transit time on the numbers of faecal anaerobes and the activities of the enzyme systems which biotransform conjugated cholic acid into unconjugated deoxycholic acid (cholylglycine hydrolase and 7α-dehydroxylase) are unknown. Methods: Therefore, in 10 non-acromegalic controls, 11 acromegalic patients not treated with octreotide, and 11 acromegalics on long term (8–48 months) octreotide (100–200 μg three times daily subcutaneously), we measured large bowel transit time and, in freshly voided faeces, the activities of the two bile acid metabolising enzymes, and related the results to the proportion of deoxycholic acid in fasting serum. Moreover, in patients with acromegaly, we measured quantitative bacteriology in faeces. Results: Mean large bowel transit time in acromegalics not treated with octreotide (35 (SEM 6.5) hours) was 66% longer than that in non-acromegalic controls (21 (3.1) hours; NS) and became further prolonged during octreotide treatment (48 (6.6) hours; p
- Subjects :
- Adult
Male
medicine.medical_specialty
Colon
medicine.drug_class
Colony Count, Microbial
Octreotide
Gallstones
Biology
Peptide hormone
Amidohydrolases
Bacteria, Anaerobic
Feces
chemistry.chemical_compound
fluids and secretions
Internal medicine
Acromegaly
medicine
Humans
Gastrointestinal Transit
Aged
Analysis of Variance
Bile acid
Cholesterol
digestive, oral, and skin physiology
Deoxycholic acid
Hydroxysteroid Dehydrogenases
Gastroenterology
Cholic acid
Fasting
Middle Aged
medicine.disease
Endocrinology
Intestinal Absorption
chemistry
Commentary
Female
Anaerobic bacteria
Constipation
Deoxycholic Acid
medicine.drug
Subjects
Details
- ISSN :
- 00175749
- Volume :
- 54
- Database :
- OpenAIRE
- Journal :
- Gut
- Accession number :
- edsair.doi.dedup.....ea640331ec3e8c5a81cc05c4d0b7e915