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Ionic Liquid-Based Ultrasonic-Assisted Extraction Coupled with HPLC and Artificial Neural Network Analysis for Ganoderma lucidum
- Source :
- Molecules, Vol 25, Iss 6, p 1309 (2020), Molecules, Volume 25, Issue 6
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Ganoderma lucidum is widely used in traditional Chinese medicine (TCM). Ganoderic acid A and D are the main bioactive components with anticancer effects in G. lucidum. To obtain the maximum content of two compounds from G. lucidum, a novel extraction method, an ionic liquid-based ultrasonic-assisted method (ILUAE) was established. Ionic liquids (ILs) of different types and parameters, including the concentration of ILs, ultrasonic power, ultrasonic time, rotational speed, solid&ndash<br />liquid ratio, were optimized by the orthogonal experiment and variance analysis. Under these optimal conditions, the total extraction yield of the two compounds in G. lucidum was 3.31 mg/g, which is 36.21% higher than that of the traditional solvent extraction method. Subsequently, an artificial neural network (ANN) was developed to model the performance of the total extraction yield. The Levenberg&ndash<br />Marquardt back propagation algorithm with the sigmoid transfer function (logsig) at the hidden layer and a linear transfer function (purelin) at the output layer were used. Results showed that single hidden layer with 9 neurons presented the best values for the mean squared error (MSE) and the correlation coefficient (R), with respectively corresponding values of 0.09622 and 0.93332.
- Subjects :
- ionic liquid (ils)
Materials science
Correlation coefficient
Mean squared error
ultrasonic-assisted method
Pharmaceutical Science
hplc
01 natural sciences
High-performance liquid chromatography
Analytical Chemistry
lcsh:QD241-441
chemistry.chemical_compound
lcsh:Organic chemistry
Drug Discovery
Physical and Theoretical Chemistry
Chromatography
010405 organic chemistry
010401 analytical chemistry
Organic Chemistry
Extraction (chemistry)
Ganoderic acid
0104 chemical sciences
ganoderma lucidum
chemistry
Chemistry (miscellaneous)
Yield (chemistry)
Ionic liquid
Molecular Medicine
Ultrasonic sensor
artificial neural network
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 25
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....ea6fba90eb7b08a33165911f714cce5e