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Independent Factors for In-Hospital Death Following Drug-Eluting Stent Thrombosis From the Japanese Adverse Event Report System
- Source :
- Circulation journal : official journal of the Japanese Circulation Society. 84(9)
- Publication Year :
- 2020
-
Abstract
- Background Stent thrombosis (ST) is a serious complication after drug-eluting stents (DES) implantation. To identify the risk factors of mortality following ST, we evaluated adverse event reports used for safety measures after approval.Methods and Results:Between July 2004 and August 2019, 2,887 ST case reports were submitted to the Pharmaceutical and Medical Device Agency. Reports of probable or possible ST (n=604), with insufficient data regarding in-hospital outcome or duration between procedure and ST occurrence (n=37) or duplicate reports (n=191) were excluded. Accordingly, 2,045 reports with definite ST were analyzed. Among the subjects, there were 286 in-hospital deaths (14.0%). Multivariate logistic regression analysis revealed that left main trunk (LMT) (odds ratio [OR]: 4.76, 95% confidence interval [CI]: 3.26-6.96), chronic heart failure (CHF) (OR: 2.88, 95% CI: 1.61-5.14), hemodialysis (OR: 2.69, 95% CI: 1.66-4.36), prior stroke (OR: 2.28, 95% CI: 1.15-4.51), over 70 years old (OR: 1.62, 95% CI: 1.22-2.16), and right coronary artery (OR: 0.41, 95% CI: 0.27-0.63) were independent factors for in-hospital death after DES-ST. Conclusions LMT, CHF, hemodialysis, prior stroke, and older age were independently associated with higher risk of in-hospital death following DES-ST. If target patients have these factors, maximum preventive strategies against ST occurrence, including adequate dual-antiplatelet therapy duration and optimal DES deployment procedures, are required.
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
Coronary Artery Disease
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Percutaneous Coronary Intervention
Japan
Renal Dialysis
Risk Factors
Internal medicine
medicine
Humans
030212 general & internal medicine
Hospital Mortality
Adverse effect
Stroke
Aged
Aged, 80 and over
Heart Failure
business.industry
Coronary Thrombosis
Age Factors
Percutaneous coronary intervention
Drug-Eluting Stents
General Medicine
Odds ratio
Middle Aged
medicine.disease
Thrombosis
Confidence interval
Treatment Outcome
Drug-eluting stent
Female
Hemodialysis
Cardiology and Cardiovascular Medicine
business
Platelet Aggregation Inhibitors
Subjects
Details
- ISSN :
- 13474820
- Volume :
- 84
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Circulation journal : official journal of the Japanese Circulation Society
- Accession number :
- edsair.doi.dedup.....ea6fc997cd4553761eca695fcca2d91d