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Isoprostane in systemic sclerosis: A systematic review and meta-analysis
- Source :
- Modern rheumatology. 29(3)
- Publication Year :
- 2018
-
Abstract
- To further the knowledge of oxidative stress in systemic sclerosis (SSc), we performed a systematic review and meta-analysis on studies measuring isoprostane, a vasoactive agent deriving from arachidonic acid and implicated in the vasculopathy of SSc.Systematic search following the PRISMA guidelines in PubMed and EMBASE between January-1990/December-2017 using the terms: oxidative stress, isoprostane, systemic sclerosis and scleroderma.After the screening process, 8 studies including 240 SSc patients and 192 controls were included in the systematic review and meta-analysis, 6 investigating urinary and 2 serum isoprostane: random effect meta-analysis revealed isoprostane overgeneration in SSc (p .001) with wide heterogeneity (IThere is some evidence for isoprostane overgeneration in SSc that confirms the occurrence of oxidative stress in this setting: further prospective studies with specified outcomes are needed to evaluate the prognostic value of this functional biomarker.
- Subjects :
- Oncology
medicine.medical_specialty
Isoprostane
systemic sclerosis
030204 cardiovascular system & hematology
Isoprostanes
medicine.disease_cause
oxidative stress
biomarkers
humans
isoprostanes
scleroderma
systemic
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Vasoactive agent
Rheumatology
Internal medicine
medicine
Humans
skin and connective tissue diseases
030203 arthritis & rheumatology
Scleroderma, Systemic
integumentary system
business.industry
Oxidative Stress
chemistry
Meta-analysis
business
Oxidative stress
Biomarkers
Subjects
Details
- ISSN :
- 14397609
- Volume :
- 29
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Modern rheumatology
- Accession number :
- edsair.doi.dedup.....ea7d0b4457beddc60c1029ecc7ffd271