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Impacts of smoking status on the clinical outcomes of coronary non-target lesions in patients with coronary heart disease: a single-center angiographic study
- Source :
- Chinese Medical Journal, Vol 133, Iss 19, Pp 2295-2301 (2020), Chinese Medical Journal
- Publication Year :
- 2020
- Publisher :
- Wolters Kluwer, 2020.
-
Abstract
- Background. Coronary atherosclerotic plaque could go through rapid progression and induce adverse cardiac events. This study aimed to evaluate the impacts of smoking status on clinical outcomes of coronary non-target lesions. Methods. Consecutive patients with coronary heart disease who underwent two serial coronary angiographies were included. All coronary non-target lesions were recorded at first coronary angiography and analyzed using quantitative coronary angiography at both procedures. Patients were grouped into non-smokers, quitters, and smokers according to their smoking status. Clinical outcomes including rapid lesion progression, lesion re-vascularization, and myocardial infarction were recorded at second coronary angiography. Multivariable Cox regression analysis was used to investigate the association between smoking status and clinical outcomes. Results. A total of 1255 patients and 1670 lesions were included. Smokers were younger and more likely to be male compared with non-smokers. Increase in percent diameter stenosis was significantly lower (2.7 [0.6, 7.1] % vs. 3.5 [0.9, 8.9]%) and 3.4 [1.1, 7.7]%, P = 0.020) in quitters than those in smokers and non-smokers. Quitters tended to have a decreased incidence of rapid lesions progression (15.8% [76/482] vs. 21.6% [74/342] and 20.6% [89/431], P = 0.062), lesion re-vascularization (13.1% [63/482] vs. 15.5% [53/432] and 15.5% [67/431], P = 0.448), lesion-related myocardial infarction (0.8% [4/482] vs. 2.6% [9/342] and 1.4% [6/431], P = 0.110) and all-cause myocardial infarction (1.9% [9/482] vs. 4.1% [14/342] and 2.3% [10/431], P = 0.128) compared with smokers and non-smokers. In multivariable analysis, smoking status was not an independent predictor for rapid lesion progression, lesion re-vascularization, and lesion-related myocardial infarction except that a higher risk of all-cause myocardial infarction was observed in smokers than non-smokers (hazards ratio: 3.00, 95% confidence interval: 1.04–8.62, P = 0.042). Conclusion. Smoking cessation mitigates the increase in percent diameter stenosis of coronary non-target lesions, meanwhile, smokers are associated with increased risk for all-cause myocardial infarction compared with non-smokers.
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
Myocardial Infarction
lcsh:Medicine
Coronary Disease
Single Center
Coronary Angiography
Lesion
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
medicine
Humans
Smoking status
Myocardial infarction
business.industry
Proportional hazards model
Incidence (epidemiology)
Hazard ratio
Rapid progression
Smoking
lcsh:R
Re-vascularization
General Medicine
Original Articles
medicine.disease
Confidence interval
Treatment Outcome
030220 oncology & carcinogenesis
Coronary non-target lesion
Cardiology
Smoking cessation
Female
medicine.symptom
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 25425641 and 03666999
- Volume :
- 133
- Issue :
- 19
- Database :
- OpenAIRE
- Journal :
- Chinese Medical Journal
- Accession number :
- edsair.doi.dedup.....ea8aa01204eb6c2f68aeb42ab2ec8388