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Eotaxin-Rich Proangiogenic Hematopoietic Progenitor Cells and CCR3+ Endothelium in the Atopic Asthmatic Response
- Source :
- Journal of immunology (Baltimore, Md. : 1950). 196(5)
- Publication Year :
- 2015
-
Abstract
- Angiogenesis is closely linked to and precedes eosinophilic infiltration in asthma. Eosinophils are recruited into the airway by chemoattractant eotaxins, which are expressed by endothelial cells, smooth muscles cells, epithelial cells, and hematopoietic cells. We hypothesized that bone marrow–derived proangiogenic progenitor cells that contain eotaxins contribute to the initiation of angiogenesis and inflammation in asthma. Whole-lung allergen challenge of atopic asthma patients revealed vascular activation occurs within hours of challenge and before airway inflammation. The eotaxin receptor CCR3 was expressed at high levels on submucosal endothelial cells in patients and a murine model of asthma. Ex vivo exposure of murine endothelial cells to eotaxins induced migration and angiogenesis. In mechanistic studies, wild-type mice transplanted with eotaxin-1/2–deficient bone marrow had markedly less angiogenesis and inflammation in an atopic asthma model, whereas adoptive transfer of proangiogenic progenitor cells from wild-type mice in an atopic asthma model into the eotaxin-1/2–deficient mice led to angiogenesis and airway inflammation. The findings indicate that Th2-promoting hematopoietic progenitor cells are rapidly recruited to the lung upon allergen exposure and release eotaxins that coordinately activate endothelial cells, angiogenesis, and airway inflammation.
- Subjects :
- 0301 basic medicine
Eotaxin
Adult
Chemokine CCL11
Hypersensitivity, Immediate
Male
Endothelium
Angiogenesis
Receptors, CCR3
Immunology
Inflammation
Bone Marrow Cells
Biology
Article
Neovascularization
03 medical and health sciences
Mice
0302 clinical medicine
Th2 Cells
immune system diseases
medicine
Immunology and Allergy
Animals
Humans
Progenitor cell
Bone Marrow Transplantation
Mice, Knockout
Neovascularization, Pathologic
Chemokine CCL24
Endothelial Cells
respiratory system
Allergens
Hematopoietic Stem Cells
Adoptive Transfer
Immunohistochemistry
Asthma
respiratory tract diseases
Endothelial stem cell
Eosinophils
Disease Models, Animal
030104 developmental biology
medicine.anatomical_structure
Case-Control Studies
Female
Bone marrow
Endothelium, Vascular
medicine.symptom
030215 immunology
Subjects
Details
- ISSN :
- 15506606
- Volume :
- 196
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Accession number :
- edsair.doi.dedup.....ea8e6e1f538e4105320b692961e37591