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Epigenetic Mechanisms and Posttranslational Modifications in Systemic Lupus Erythematosus
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- REDICUC-Repositorio CUC, Corporación Universidad de la Costa, instacron:Corporación Universidad de la Costa, International Journal of Molecular Sciences, Vol. 20, No. 22 (2019), Wu, H.; Zhao, M.; Tan, L.; Lu, Q. The key culprit in the pathogenesis of systemic lupus erythematosus: Aberrant DNA methylation. Autoimmun. Rev. 2016, 15, 684–689., Rhodes, B.; Vyse, T.J. The genetics of SLE: An update in the light of genome-wide association studies. Rheumatology (Oxford) 2008, 47, 1603–1611., Quddus, J.; Johnson, K.J.; Gavalchin, J.; Amento, E.P.; Chrisp, C.E.; Yung, R.L.; Richardson, B.C. Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is su cient to cause a lupus-like disease in syngeneic mice. J. Clin. Invest. 1993, 92, 38–53., Coit, P.; Yalavarthi, S.; Ognenovski, M.; Zhao, W.; Hasni, S.; Wren, J.D.; Kaplan, M.J.; Sawalha, A.H. 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Ph.D. Thesis, Universidad de Sevilla, Seville, Spain, December 2013., Repositorio Digital USB, Universidad Simón Bolívar, instacron:Universidad Simón Bolívar
- Publication Year :
- 2019
- Publisher :
- MDPI AG, 2019.
-
Abstract
- The complex physiology of eukaryotic cells is regulated through numerous mechanisms, including epigenetic changes and posttranslational modifications. The wide-ranging diversity of these mechanisms constitutes a way of dynamic regulation of the functionality of proteins, their activity, and their subcellular localization as well as modulation of the differential expression of genes in response to external and internal stimuli that allow an organism to respond or adapt to accordingly. However, alterations in these mechanisms have been evidenced in several autoimmune diseases, including systemic lupus erythematosus (SLE). The present review aims to provide an approach to the current knowledge of the implications of these mechanisms in SLE pathophysiology.
- Subjects :
- 0301 basic medicine
Glycosylation
Epigenetic mechanisms
epigenetic mechanisms
SUMO protein
Review
Biology
ubiquitination
Hydroxylation
Catalysis
Epigenesis, Genetic
Inorganic Chemistry
03 medical and health sciences
Systemic lupus erythematosus
0302 clinical medicine
systemic lupus erythematosus
Ubiquitin
Animals
Humans
Lupus Erythematosus, Systemic
Sulfation
Epigenetics
Phosphorylation
Physical and Theoretical Chemistry
Differential expression
skin and connective tissue diseases
Molecular Biology
Gene
Spectroscopy
Organism
030203 arthritis & rheumatology
phosphorylation
Organic Chemistry
sulfation
Ubiquitination
Acetylation
General Medicine
Subcellular localization
SUMOylation
Computer Science Applications
030104 developmental biology
Posttranslational modifications
biology.protein
posttranslational modifications
Protein Processing, Post-Translational
Neuroscience
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....ea98e2ae0f505b0ba6c7b8978a077a0d
- Full Text :
- https://doi.org/10.3390/ijms20225679