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Phonological picture-word interference in language mapping with transcranial magnetic stimulation: an objective approach for functional parcellation of Broca's region
- Source :
- Brain structurefunction. 224(6)
- Publication Year :
- 2018
-
Abstract
- Functional imaging data suggest different regions for semantic, syntactic, and phonological processing in an anterior-to-posterior direction along the inferior frontal gyrus. Language mapping by use of neuro-navigated transcranial magnetic stimulation (TMS) is frequently applied in clinical research to identify language-related cortical regions. Recently, we proposed a high spatial resolution approach for more detailed language mapping of cortical sub-areas such as Broca’s region. Here, we employed a phonological picture–word interference paradigm in healthy subjects to reveal functional specialization in Broca’s region for phonological processing. The behavioral phonological priming effect is characterized by accelerated naming responses to target pictures accompanied by phonologically related auditory distractor words. We hypothesized that the inhibitory effects of TMS on language processing would reduce phonological priming only at stimulation sites involved in phonological processing. In active as compared to sham TMS, we found reduced phonological facilitation specifically at sites overlapping with the probabilistic cytoarchitectonic area 44. Our findings complemented functional imaging data by revealing structure–function relationship in Broca’s region. The introduction of a reaction time based interference paradigm into TMS language mapping increases the objectivity of the method and allows to explore functional specificity with high temporal resolution. Findings may help to interpret results in clinical applications.
- Subjects :
- Adult
Male
Histology
medicine.medical_treatment
Inferior frontal gyrus
Language mapping
050105 experimental psychology
03 medical and health sciences
Young Adult
0302 clinical medicine
medicine
Image Processing, Computer-Assisted
Reaction Time
Humans
Speech
0501 psychology and cognitive sciences
Language
Cerebral Cortex
Brain Mapping
General Neuroscience
05 social sciences
Functional specialization
Middle Aged
Magnetic Resonance Imaging
Transcranial Magnetic Stimulation
Broca Area
Broca's region
Transcranial magnetic stimulation
Functional imaging
Facilitation
Female
Anatomy
Psychology
Neuroscience
Priming (psychology)
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 18632661
- Volume :
- 224
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Brain structurefunction
- Accession number :
- edsair.doi.dedup.....eab98cb83668e92b9bc759c71f9de98d