Back to Search
Start Over
Treatment effectiveness and treatment patterns among rheumatoid arthritis patients after switching from a tumor necrosis factor inhibitor to another medication
- Source :
- ClinicoEconomics and Outcomes Research: CEOR
- Publication Year :
- 2016
- Publisher :
- Informa UK Limited, 2016.
-
Abstract
- Objectives After treatment failure with a tumor necrosis factor inhibitor (TNFi), patients with rheumatoid arthritis (RA) can switch to another TNFi (TNFi cyclers) or to a targeted disease-modifying antirheumatic drug (DMARD) with a non-TNFi mechanism of action (non-TNFi switchers). This study compared treatment patterns and treatment effectiveness between TNFi cyclers and non-TNFi switchers in patients with RA. Methods The analysis included a cohort of patients from the Truven Health Analytics MarketScan Commercial database with RA who switched from a TNFi (adalimumab, certolizumab pegol, etanercept, golimumab, or infliximab) either to another TNFi or to a non-TNFi targeted DMARD (abatacept, tocilizumab, or tofacitinib) between January 1, 2010 and September 30, 2014. A claims-based algorithm was used to estimate treatment effectiveness based on six criteria (adherence, no dose increase, no new conventional therapy, no switch to another targeted DMARD, no new/increased oral glucocorticoid, and intra-articular injections on
- Subjects :
- rheumatoid arthritis
musculoskeletal diseases
medicine.medical_specialty
Economics, Econometrics and Finance (miscellaneous)
Etanercept
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Adalimumab
030212 general & internal medicine
Certolizumab pegol
tumor necrosis factor inhibitor
Original Research
030203 arthritis & rheumatology
Tofacitinib
switching
business.industry
Health Policy
Abatacept
medicine.disease
Golimumab
Infliximab
Rheumatoid arthritis
Physical therapy
business
biologic
medicine.drug
Subjects
Details
- ISSN :
- 11786981
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- ClinicoEconomics and Outcomes Research
- Accession number :
- edsair.doi.dedup.....eae6fb8ca81767b488355c032c9e8915
- Full Text :
- https://doi.org/10.2147/ceor.s115706