Differentiation of esophageal pH-impedance characteristics classified by the mucosal integrity marker in human neonates

BACKGROUND: In adults, distal baseline impedance (BI) is a determinant of esophageal mucosal integrity with values 2000Ω). Regression analysis was used to identify potential contributing factors of BI. RESULTS: In BI2000Ω), and 2) positive symptom correlations were noted with bolus (73%) and acid events (55%). Significant predictors of BI included chronological age, acid reflux index, and BPD diagnosis (all P2000Ω likely involves little or no inflammation because acid exposure is minimal. Combination of SAP, pH-impedance metrics and BI along with clarification of dysmotility mechanisms provides the rationale for personalized anti-reflux therapies as needed.