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Effects of competitive physical activity on serum irisin levels and bone turnover markers
- Source :
- Journal of Endocrinological Investigation
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Background Irisin, a myokine, is a polypeptide derived from the cleavage of the extracellular domain of fibronectin domain-containing protein 5, a receptor that is present on different tissues (skeletal muscle, pericardium, myocardium, and brain), whose functions are not yet fully defined. Purpose The main aim of our study was to evaluate the effect of competitive physical activity on serum irisin levels and bone turnover markers. Methods Fifteen male footballers and an equal number of subjects of the same age and gender, but with a predominantly sedentary lifestyle, had their serum levels of irisin and bone turnover markers measured. Bone mineral status was evaluated in both groups by quantitative bone ultrasound of the calcaneus. In addition, only in footballers, biochemical analyses were repeated after 3 months. Results We did not observe significant differences in the serum levels of calcium, phosphorus, and parathyroid hormone between the two groups. The footballers had significantly higher quantitative bone ultrasound, 25-OH vitamin D, and creatinine values than the controls. There were also no significant differences in the bone alkaline phosphatase, carboxy-terminal telopeptide of type I collagen, osteoprotegerin, sclerostin or Dkk-1 values, while the irisin levels (+ 89%, p Conclusion Our study shows that footballers have significantly higher serum irisin values than the general population. Irisin could be the "trait d’union" between bone health and physical activity.
- Subjects :
- Adult
Male
0301 basic medicine
Irisin
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Population
Football
Parathyroid hormone
030209 endocrinology & metabolism
Athletic Performance
Bone remodeling
Young Adult
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
N-terminal telopeptide
Osteoprotegerin
Internal medicine
Myokine
medicine
Humans
Bone
education
Exercise
Bone mineral
education.field_of_study
Physical activity
business.industry
Prognosis
Fibronectins
030104 developmental biology
chemistry
Case-Control Studies
Muscle
Myokines
Sclerostin
Original Article
Female
Bone Remodeling
Sedentary Behavior
business
Biomarkers
Follow-Up Studies
Subjects
Details
- ISSN :
- 17208386
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Journal of Endocrinological Investigation
- Accession number :
- edsair.doi.dedup.....eb1f1a20f25c9df2bbc558befb3456ba