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Increased ratio of neutrophil elastase to α1-antitrypsin is closely associated with liver inflammation in patients with nonalcoholic steatohepatitis
- Source :
- Clinical and experimental pharmacologyphysiology. 43(1)
- Publication Year :
- 2015
-
Abstract
- An imbalance between neutrophil elastase (NE) and its inhibitor α1-antitrypsin (A1 AT) is known to contribute to the development of obesity-related inflammation. This study aimed to investigate the role of the NE-A1 AT system in the histological progression of non-alcoholic fatty liver disease (NAFLD), and to evaluate the ability of it to predict nonalcoholic steatohepatitis (NASH). A total of 252 adults (NAFLD group, n = 202; healthy group, n = 50) were recruited. Clinical biochemical characteristics, NE and A1 AT concentrations were measured in all subjects. Among the NAFLD group, 86 patients had previously undergone liver biopsy and information on histological characteristics was consequently available. The area under the receiver operating characteristic curve (AUC) was used to determine the predictive accuracy of the NE-A1 AT system for NASH. NAFLD patients had an elevated serum NE concentration and a reduced A1 AT level with consequent NE/A1 AT imbalance. NE increased in the early stage of steatosis, preceding the decline in A1 AT, dating from the onset of NASH (NAS 3-4), and subsequently NE/A1 AT increased in the presence of NASH. Nonetheless, this increase began to resolve as the disease state progressed to advanced fibrosis. A1 AT had a sensitivity (SEN) of 83.8% and a specificity (SP) of 83.3% with the optimal cut-off of -1459.43, NE/A1 AT had a SEN of 88.8% and a SP of 83.3% with cut-off of 0.363 to predict NASH. An increased NE: A1 AT ratio is closely associated with liver Inflammation in patients with NASH and could serve as a novel marker to predict NASH in humans.
- Subjects :
- 0301 basic medicine
Adult
Blood Glucose
Male
medicine.medical_specialty
Physiology
Neutrophils
Inflammation
digestive system
Gastroenterology
03 medical and health sciences
Insulin resistance
Fibrosis
Non-alcoholic Fatty Liver Disease
Physiology (medical)
Internal medicine
medicine
Humans
Pharmacology
biology
medicine.diagnostic_test
business.industry
Fatty liver
Case-control study
nutritional and metabolic diseases
medicine.disease
digestive system diseases
030104 developmental biology
Liver
Neutrophil elastase
Liver biopsy
Case-Control Studies
alpha 1-Antitrypsin
biology.protein
Disease Progression
Female
Steatosis
medicine.symptom
Insulin Resistance
business
Leukocyte Elastase
Subjects
Details
- ISSN :
- 14401681
- Volume :
- 43
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Clinical and experimental pharmacologyphysiology
- Accession number :
- edsair.doi.dedup.....eb2abc92fd4c9b4dc17cdcd85b3ca96b